INT200136

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.91
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2)
helicase activity (ERCC2) extracellular matrix organization (ERCC2) DNA binding (ERCC2)
ERCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 12 65.12 Quite High
Paracetamol 10 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cockayne Syndrome 36 97.08 Very High Very High Very High
Death 16 95.32 Very High Very High Very High
Lifespan 13 94.56 High High
Osteoporosis 1 93.32 High High
Kyphosis 6 92.76 High High
Retina Disease 7 90.72 High High
Sensorineural Hearing Loss 1 89.84 High High
Gait Ataxia 1 88.72 High High
Microcephaly 1 88.20 High High
Intellectual Impairment 1 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHO AA8 cells served as the original source of the UV5 line, which lacks nucleotide excision repair (NER) due to an induced defect in the XPD (ERCC2) gene (70,71).
Negative_regulation (defect) of ERCC2
1) Confidence 0.37 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0.03
CHO AA8 cells served as the original source of the UV5 line, which lacks nucleotide excision repair (NER) due to an induced defect in the XPD (ERCC2) gene (70,71).
Negative_regulation (defect) of XPD
2) Confidence 0.37 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0.03
TTD patients are partially defective in TCR as well as in the GG-NER, and share the symptoms associated with CS.
Spec (partially) Negative_regulation (defective) of TTD associated with cockayne syndrome
3) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 1.91 Pain Relevance 0

General Comments

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