INT200164

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 2.35
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dmd) cytoskeleton (Dmd) nucleus (Dmd)
cytoplasm (Dmd)
Anatomy Link Frequency
muscle 1
vein 1
synapse 1
Dmd (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 11 90.64 High High
Inflammation 1 90.12 High High
Neurotransmitter 132 88.80 High High
Neuronal nitric oxide synthase 7 86.20 High High
Hippocampus 72 71.36 Quite High
sodium channel 21 66.72 Quite High
Glutamate 18 65.12 Quite High
Peripheral nervous system 12 60.12 Quite High
ischemia 6 50.16 Quite High
Glutamate receptor 36 34.80 Quite Low
Disease Link Frequency Relevance Heat
Arrhythmias 2 Under Development 1 99.12 Very High Very High Very High
Disease 34 98.74 Very High Very High Very High
Muscular Dystrophy 364 98.16 Very High Very High Very High
Death 17 97.68 Very High Very High Very High
Helminth Infection 42 96.56 Very High Very High Very High
Targeted Disruption 90 94.80 High High
Congenital Anomalies 78 94.24 High High
Fibrosis 13 90.64 High High
INFLAMMATION 1 90.12 High High
Necrosis 9 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies using these invertebrate models, where electrophysiology can be combined with genetic manipulation of single identified cells, should continue to reveal the molecules with which dystrophin interacts at the synapse.
dystrophin Binding (interacts) of in synapse
1) Confidence 0.42 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.07 Pain Relevance 0.21
Perloff et al. suggested that the alteration of a particular ionic current by lack of specific membrane proteins associated with dystrophin might participate in electrocardiographic changes [17].
dystrophin Binding (associated) of associated with arrhythmias 2 under development
2) Confidence 0.35 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1698931 Disease Relevance 0.69 Pain Relevance 0.13
While resting membrane potentials were not affected by the absence of dystrophin, the shift in the inactivation curve itself is sufficient to cause an approximately twofold higher activity of Nav1.4 channels at the measured Vrest of approximately ?
dystrophin Neg (absence) Binding (absence) of
3) Confidence 0.34 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
Dystrophin also interacts with BMP signaling pathways in the Drosophila wing where their interplay is required for proper vein formation [106].
Dystrophin Binding (interacts) of in vein
4) Confidence 0.33 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0 Pain Relevance 0.03
The cysteine-rich region and the C terminus of dystrophin establish the link with the DGC through binding to ?
dystrophin Binding (binding) of
5) Confidence 0.33 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0 Pain Relevance 0.06
Calmodulin is likely to regulate binding of dystrophin/utrophin to actin [87], while the Ca2+/calmodulin dependent kinase, CaMKII, actively phosphorylates both dystrophin and syntrophin [88].
dystrophin Spec (likely) Binding (binding) of
6) Confidence 0.33 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.34 Pain Relevance 0.03
For example, it has a dystrophin gene, but no utrophin, DRP2, or sarcospan genes, single dystrobrevin and dystroglycan genes, and three sarcoglycan and two syntrophin orthologs (TableĀ 1).
dystrophin Neg (no) Binding (has) of
7) Confidence 0.33 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.10 Pain Relevance 0.03
It has been recently established that dystrophin itself can also serve as a scaffold for nNOS sarcolemmal targeting [72].How do alterations in NO levels result in changes in UGC function?
dystrophin Binding (serve) of
8) Confidence 0.29 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.37 Pain Relevance 0.06
Duchenne muscular dystrophy (DMD) is a fatal x-linked disease caused by mutations in the gene encoding the 427 kDa membrane-associated cytoskeletal protein dystrophin, resulting in progressive body-wide muscle weakening and death usually in the early to mid third decade of life.
dystrophin Binding (associated) of in muscle associated with muscular dystrophy, disease and death
9) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0.55 Pain Relevance 0
Transduction efficiency was assessed by immuno-staining using an antibody (Manex1a) that recognizes the N-terminus of micro-dystrophin.
micro-dystrophin Binding (recognizes) of
10) Confidence 0.06 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2082019 Disease Relevance 0.24 Pain Relevance 0

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