INT200180

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
liver 4
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 11 74.88 Quite High
Intracerebroventricular 1 72.96 Quite High
Bioavailability 1 8.92 Low Low
Somatostatin 22 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dwarfism 25 97.68 Very High Very High Very High
Hutchinson-gilford Progeria Syndrome 41 83.80 Quite High
Body Weight 30 74.80 Quite High
Syndrome 21 72.16 Quite High
Hypertrophy 2 64.48 Quite High
Acromegaly 27 60.52 Quite High
Hypoglycemia 6 58.56 Quite High
Stress 25 50.00 Quite Low
Aging 34 45.84 Quite Low
Hyperinsulinism 7 44.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a relative trend of decreased insulin requirement of GhrR KO mice was maintained throughout the 2nd phase of insulin release [18], and reaching its maximal effect at the point of HG clamp.
Negative_regulation (decreased) of Localization (requirement) of GhrR
1) Confidence 0.35 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.19 Pain Relevance 0
Comparable questions may be asked for effects observed in organs other than the liver, ie, are eventual changes in organ responses the result of diminished liver IGF-I synthesis and subsequent decrease in circulating IGF-I or are effects also (or mainly) mediated via local blocking of the GH receptor?
Negative_regulation (blocking) of Localization (local) of GH receptor in liver
2) Confidence 0.33 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.07
Indeed, liver GHR mRNA abundance was significantly reduced in both XPCS/XPA and CH/XPA pups.
Negative_regulation (reduced) of Localization (abundance) of GHR mRNA in liver
3) Confidence 0.32 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.52 Pain Relevance 0

General Comments

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