INT200186

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.46
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Igfals) cell adhesion (Igfals) nucleus (Igfals)
Anatomy Link Frequency
neuronal 1
endothelial cells 1
nerve 1
muscle 1
Igfals (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 30 100.00 Very High Very High Very High
Spinal cord 59 99.38 Very High Very High Very High
carpal tunnel syndrome 216 92.96 High High
Inflammation 18 88.44 High High
Demyelination 6 81.32 Quite High
medulla 5 78.96 Quite High
Central nervous system 14 59.88 Quite High
Inflammatory response 9 47.12 Quite Low
Glutamate 1 15.04 Low Low
Hippocampus 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 223 100.00 Very High Very High Very High
Hypoglycemia 7 98.92 Very High Very High Very High
Hyperinsulinism 1 97.84 Very High Very High Very High
Neurodegenerative Disease 17 94.60 High High
Carpal Tunnel Syndrome 220 92.96 High High
Aging 34 92.00 High High
Spinal Muscular Atrophy 7 89.52 High High
Death 37 89.16 High High
INFLAMMATION 28 88.44 High High
Demyelinating Disease 9 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was also evidence of IgG intake in endothelial cells in affected areas of the spinal cord in both ALS patients and mice injected with human ALS IgG.
ALS Binding (injected) of in endothelial cells associated with motor neuron diseases and spinal cord
1) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.59 Pain Relevance 0.22
IGF-1, IGF-1 binding protein 3 (IGF-BP3, also known as GH-dependent binding protein), and acid-labile subunit (ALS) form a ternary complex in the serum and are all reduced in GH insensitivity disorders in proportion to the severity of GH resistance [38].
ALS Binding (binding) of
2) Confidence 0.13 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.51 Pain Relevance 0
CTS: carpal tunnel syndrome; ABP: Abductor Pollicis Brevis; DQEMG: decomposition-based quantitative electromyography; EMG: electromyographyl; RMS: root mean square; MU: motor unit; MUP: needle-detected motor unit potential; MUPT: motor unit potential train; MUNE: motor unit number estimate; MVC: maximal voluntary contraction; SMUP: surface-detected motor unit potential; CMAP: compound muscle action potential; CNAP: compound nerve action potential; ALS: amyotrophic lateral sclerosis; SNAP: sensory nerve action potential; RMSMVC: RMS value of the MVC.


ALS Binding (compound) of in muscle associated with action potential, carpal tunnel syndrome and motor neuron diseases
3) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.67 Pain Relevance 0.57
CTS: carpal tunnel syndrome; ABP: Abductor Pollicis Brevis; DQEMG: decomposition-based quantitative electromyography; EMG: electromyographyl; RMS: root mean square; MU: motor unit; MUP: needle-detected motor unit potential; MUPT: motor unit potential train; MUNE: motor unit number estimate; MVC: maximal voluntary contraction; SMUP: surface-detected motor unit potential; CMAP: compound muscle action potential; CNAP: compound nerve action potential; ALS: amyotrophic lateral sclerosis; SNAP: sensory nerve action potential; RMSMVC: RMS value of the MVC.


ALS Binding (compound) of in nerve associated with action potential, carpal tunnel syndrome and motor neuron diseases
4) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.66 Pain Relevance 0.56
Fifteen loci are known to be associated with ALS, and eight causative genes have been identified, the most common of which is SOD1 (Cu/Zn superoxide dismutase 1) [2].
ALS Binding (associated) of associated with motor neuron diseases
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 1.24 Pain Relevance 0.08
Data on the interaction of neurons with glial cells in the context of ALS are still patchy, but there is a growing understanding that non-neuronal cells have a fundamental role to play in the pathogenesis of neurodegenerative diseases [119].
ALS Binding (interaction) of in neuronal associated with neurodegenerative disease and motor neuron diseases
6) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.78 Pain Relevance 0.09

General Comments

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