INT200189

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.19
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Igfals) cell adhesion (Igfals) nucleus (Igfals)
Anatomy Link Frequency
motor neuron 2
blood 1
neuronal 1
liver 1
nerve 1
Igfals (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 15 100.00 Very High Very High Very High
Multiple sclerosis 29 99.76 Very High Very High Very High
Spinal cord 47 94.08 High High
carpal tunnel syndrome 108 91.72 High High
Pain 12 91.32 High High
medulla 29 90.80 High High
Demyelination 3 78.84 Quite High
cerebral cortex 2 77.08 Quite High
Central nervous system 42 75.52 Quite High
Inflammatory mediators 2 61.44 Quite High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 141 100.00 Very High Very High Very High
Disease 77 100.00 Very High Very High Very High
Multiple Sclerosis 28 99.76 Very High Very High Very High
Death 43 99.00 Very High Very High Very High
Gliosis 2 98.56 Very High Very High Very High
Frontotemporal Dementia 2 95.44 Very High Very High Very High
Hypoglycemia 18 95.00 High High
Hyperinsulinism 2 93.92 High High
Dementia 24 93.44 High High
Epilepsy 7 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In XPCS/XPA and CH/XPA animals, liver IGF-BP3 and ALS mRNA levels were reduced in addition to that of IGF-1, although the reduction in ALS expression in CH/XPA did not meet the criteria for statistical significance (Figure 4C and unpublished data).
Negative_regulation (reduced) of ALS in liver
1) Confidence 0.24 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.39 Pain Relevance 0
IGF-1, IGF-1 binding protein 3 (IGF-BP3, also known as GH-dependent binding protein), and acid-labile subunit (ALS) form a ternary complex in the serum and are all reduced in GH insensitivity disorders in proportion to the severity of GH resistance [38].
Negative_regulation (reduced) of ALS
2) Confidence 0.15 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.49 Pain Relevance 0
In a recent study, a connection between VGLUT2 gene expression and ALS was shown, which specified a role for VGLUT2 in motor neuron survival.
Negative_regulation (connection) of ALS in motor neuron associated with motor neuron diseases
3) Confidence 0.14 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.52 Pain Relevance 0.20
CTS: carpal tunnel syndrome; ABP: Abductor Pollicis Brevis; DQEMG: decomposition-based quantitative electromyography; EMG: electromyographyl; RMS: root mean square; MU: motor unit; MUP: needle-detected motor unit potential; MUPT: motor unit potential train; MUNE: motor unit number estimate; MVC: maximal voluntary contraction; SMUP: surface-detected motor unit potential; CMAP: compound muscle action potential; CNAP: compound nerve action potential; ALS: amyotrophic lateral sclerosis; SNAP: sensory nerve action potential; RMSMVC: RMS value of the MVC.


Negative_regulation (potential) of ALS in nerve associated with action potential, carpal tunnel syndrome and motor neuron diseases
4) Confidence 0.13 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.66 Pain Relevance 0.56
These data suggest that BV-treatment at ST36 had a neuroprotective effect via activation of a cell survival signal transduction pathway, which reduced ALS-associated motor neuron death from gliosis and neuroinflammation.


Negative_regulation (reduced) of ALS in motor neuron associated with gliosis, death and motor neuron diseases
5) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.53 Pain Relevance 0.32
In all cases neurological investigations including haematological and biochemical blood tests, CSF analysis, neuroimaging and neurophysiological evaluation were compatible with a diagnosis of ALS.
Negative_regulation (diagnosis) of ALS in blood associated with motor neuron diseases
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.71 Pain Relevance 0
Conditions such as MS, PD, and ALS are increasingly being investigated for possible disruption of the BBB or the BSB.11–13 Zlokovic107 asserts BBB breakdown due to the disruption of the tight junctions may initiate and or contribute to a “vicious circle” of disease process resulting in progression synaptic and neuronal dysfunction and loss in disorders including PD, ALS, and MS.
Negative_regulation (loss) of ALS in neuronal associated with multiple sclerosis, disease and motor neuron diseases
7) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.89 Pain Relevance 0.31

General Comments

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