INT200198

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.51
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 4
endometrium 3
body 2
ovary 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 7 96.32 Very High Very High Very High
sodium channel 2 89.76 High High
Somatostatin 72 63.12 Quite High
Eae 4 58.48 Quite High
nMDA receptor 1 53.36 Quite High
Sciatic nerve 1 47.52 Quite Low
Hippocampus 12 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 54 99.78 Very High Very High Very High
Body Weight 22 99.04 Very High Very High Very High
Lung Cancer 14 98.78 Very High Very High Very High
Hutchinson-gilford Progeria Syndrome 82 97.56 Very High Very High Very High
Cancer 136 97.48 Very High Very High Very High
Acromegaly 72 96.96 Very High Very High Very High
Adenoma 43 92.64 High High
Syndrome 52 91.20 High High
Pancreatic Cancer 16 90.24 High High
Disease 28 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed above, epidemiological studies have clearly demonstrated that controlling GH and IGF-I secretion is the most significant determinant of restoring survival in patients with acromegaly The main goal of treatment of acromegaly is therefore to achieve GH levels of less than 1 ?
Regulation (controlling) of Localization (secretion) of IGF-I associated with acromegaly
1) Confidence 0.58 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.71 Pain Relevance 0
As a control, relative abundance of IGF-1 and a number of other mRNAs in single mutant XPA, XPCS, and TTD livers was not significantly different from heterozygous controls (unpublished data).
Regulation (control) of Localization (abundance) of IGF-1 in livers associated with hutchinson-gilford progeria syndrome
2) Confidence 0.40 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.70 Pain Relevance 0
GH mediates its effects largely through the increased secretion of insulin-like growth factor 1 (IGF-1) in target tissues including the liver.
Regulation (effects) of Localization (secretion) of insulin-like growth factor 1 in liver
3) Confidence 0.24 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.96 Pain Relevance 0
Recently, our group has demonstrated that PTPH1 dephosphorylates GHR in vitro and in cellular assays [21] and results in an increase of body weight in the functional PTPH1-knockout (KO) mice via modulation of IGF1 secretion [22] thus demonstrating its in vivo relevance.
Regulation (modulation) of Localization (secretion) of IGF1 in body associated with targeted disruption and body weight
4) Confidence 0.22 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.43 Pain Relevance 0.10
GHRH and its receptor are also expressed in cancers of the breast, ovary, and endometrium and small-cell lung cancer, and may function as a paracrine/autocrine growth factor in regulating local IGF-I and/or IGF-II secretion.
Regulation (regulating) of Localization (secretion) of IGF-I in endometrium associated with lung cancer and cancer
5) Confidence 0.20 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.86 Pain Relevance 0.12
GHRH and its receptor are also expressed in cancers of the breast, ovary, and endometrium and small-cell lung cancer, and may function as a paracrine/autocrine growth factor in regulating local IGF-I and/or IGF-II secretion.
Regulation (regulating) of in ovary Localization (secretion) of IGF-I in endometrium associated with lung cancer and cancer
6) Confidence 0.07 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.86 Pain Relevance 0.12

General Comments

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