INT200200

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 1 87.32 High High
Somatostatin 46 84.48 Quite High
cytokine 5 72.72 Quite High
headache 2 63.92 Quite High
tolerance 5 48.00 Quite Low
carpal tunnel syndrome 1 25.12 Quite Low
agonist 8 5.00 Very Low Very Low Very Low
Dopamine 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 34 99.72 Very High Very High Very High
Stress 21 98.36 Very High Very High Very High
Acromegaly 36 97.12 Very High Very High Very High
Hematological Disease 10 96.72 Very High Very High Very High
Helminth Infection 1 95.20 Very High Very High Very High
Starvation 3 93.04 High High
Hypoglycemia 6 89.76 High High
Cv General 3 Under Development 1 87.32 High High
Apnoea 2 86.20 High High
Coronary Heart Disease 6 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in mortality observed in acromegaly is likely to be due to the introduction of effective therapies such as transsphenoidal surgery in the 1970s and to postoperative radiotherapy, leading to normalization of GH and IGF-I concentrations in a substantial number of patients.
Positive_regulation (leading) of Negative_regulation (normalization) of IGF-I associated with acromegaly
1) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 1.06 Pain Relevance 0.15
Reduced serum IGF-1 can be caused by genetic defects in structural components of the somatotropic axis itself (Ames and Snell dwarfs and GHR-KO mice) or by an adaptive response to environmental cues such as starvation or calorie restriction.
Positive_regulation (caused) of Negative_regulation (Reduced) of IGF-1 associated with starvation
2) Confidence 0.41 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.79 Pain Relevance 0
In our model, treatment with rhGH significantly increases systemic level of IGF-1 (Fig. 6).
Positive_regulation (increases) of Negative_regulation (level) of IGF-1
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.48 Pain Relevance 0.07

General Comments

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