INT200206

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.83
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Igfals) cell adhesion (Igfals) nucleus (Igfals)
Anatomy Link Frequency
liver 2
astrocytes 2
motor neuron 2
T cells 2
Igfals (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 13 99.10 Very High Very High Very High
Multiple sclerosis 46 99.00 Very High Very High Very High
Pain 6 91.32 High High
Substantia nigra 8 84.20 Quite High
cerebral cortex 2 77.08 Quite High
Central nervous system 52 72.88 Quite High
Thalamus 7 61.28 Quite High
Inflammatory mediators 4 60.56 Quite High
Glutamate 36 50.00 Quite Low
Neuropeptide 26 50.00 Quite Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 42 100.00 Very High Very High Very High
Dementia 18 99.98 Very High Very High Very High
Chronic Fatigue Syndrome 22 99.84 Very High Very High Very High
Multiple Sclerosis 56 99.00 Very High Very High Very High
Syndrome 21 96.62 Very High Very High Very High
Vascular Dementia 2 94.52 High High
Epilepsy 7 91.84 High High
Pain 6 91.32 High High
Cognitive Disorder 5 90.30 High High
Disease 62 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In XPCS/XPA and CH/XPA animals, liver IGF-BP3 and ALS mRNA levels were reduced in addition to that of IGF-1, although the reduction in ALS expression in CH/XPA did not meet the criteria for statistical significance (Figure 4C and unpublished data).
Negative_regulation (reduction) of Gene_expression (expression) of ALS in liver
1) Confidence 0.21 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.38 Pain Relevance 0
In a recent study, a connection between VGLUT2 gene expression and ALS was shown, which specified a role for VGLUT2 in motor neuron survival.
Negative_regulation (connection) of Gene_expression (expression) of ALS in motor neuron associated with motor neuron diseases
2) Confidence 0.14 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.52 Pain Relevance 0.20
In a series of ALS patients, CSF levels of VIP were found to be significantly lower compared with controls.62 VIP has demonstrated potent effects on neurite outgrowth in spinal cord cultures suggesting its use in treatment of ALS.63 Interestingly Sun and colleagues64 noted impaired VIP receptor (VPAC2) production in activated T cells in MS patients, suggesting transcription irregularity at promoter regions of the VPAC2 gene.
Negative_regulation (impaired) of Gene_expression (production) of ALS in T cells associated with multiple sclerosis, motor neuron diseases and spinal cord
3) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.33 Pain Relevance 0.27
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Negative_regulation (however) of Gene_expression (recognized) of ALS in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
4) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.61 Pain Relevance 0.03

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