INT200212

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.10
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EPAS1, VHL) nucleus (EPAS1, VHL) transcription factor binding (EPAS1, VHL)
cell differentiation (EPAS1) mitochondrion (VHL) cell morphogenesis (VHL)
EPAS1 (Homo sapiens)
VHL (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 9 54.96 Quite High
Catecholamine 61 43.52 Quite Low
Central nervous system 2 24.08 Low Low
Dopamine 7 21.04 Low Low
imagery 28 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
medulla 5 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 127 100.00 Very High Very High Very High
Syndrome 63 100.00 Very High Very High Very High
Hypoxia 4 97.92 Very High Very High Very High
Paraganglioma 97 85.40 High High
Pheochromocytoma 134 80.84 Quite High
Neuroendocrine Cancer 2 80.32 Quite High
Disease 69 77.04 Quite High
Hypertension 32 69.12 Quite High
Renal Cancer 7 58.88 Quite High
Hemangioma 2 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The VHL tumor suppressor protein (pVHL) also interacts with HIF after post-translational prolyl-hydroxylation.
HIF Binding (interacts) of VHL associated with cancer
1) Confidence 0.06 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.30 Pain Relevance 0.03
The VHL tumor suppressor protein (pVHL) also interacts with HIF after post-translational prolyl-hydroxylation.
HIF Binding (interacts) of pVHL associated with cancer
2) Confidence 0.06 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.29 Pain Relevance 0.03
From in vivo experiments in mice, Hoffmann et al., has described a group of VHL type 2C mutants which all retained the ability to interact with HIF and to down regulate HIF target genes when reintroduced into pVHL defective tumour cells.
HIF Binding (interact) of VHL associated with cancer and syndrome
3) Confidence 0.02 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2169240 Disease Relevance 1.51 Pain Relevance 0

General Comments

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