INT200213

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.43
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PAH, SDHD) cytosol (PAH) transport (SDHD)
mitochondrion (SDHD) cellular nitrogen compound metabolic process (PAH)
Anatomy Link Frequency
germline 1
PAH (Homo sapiens)
SDHD (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 30 87.68 High High
imagery 12 43.36 Quite Low
Dopamine 3 41.48 Quite Low
Somatostatin 1 38.08 Quite Low
noradrenaline 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 50 100.00 Very High Very High Very High
Paraganglioma 48 100.00 Very High Very High Very High
Disease 20 99.70 Very High Very High Very High
Cancer 53 95.64 Very High Very High Very High
Watson Syndrome 5 94.20 High High
Hyperplasia 1 79.60 Quite High
Stroke 1 66.08 Quite High
Heart Rate Under Development 7 65.64 Quite High
Myocardial Infarction 1 64.96 Quite High
Anxiety Disorder 3 57.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior to 2000, three different familial and syndromic diseases were known to result in PGL and/or PH: MEN-2 induced by germline inactivating mutations in the RET proto-oncogene; VHL disease due to mutations in the tumor suppressor gene VHL; and NF1 caused by mutations in the NF1 gene.
PH Positive_regulation (result) of PGL in germline associated with cancer, paraganglioma, watson syndrome, disease and pheochromocytoma
1) Confidence 0.21 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.43 Pain Relevance 0.10

General Comments

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