INT200216

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.51
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHD) mitochondrion (SDHD) small molecule metabolic process (SDHD)
SDHD (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 69 98.40 Very High Very High Very High
Neuropeptide 6 97.56 Very High Very High Very High
headache 7 97.32 Very High Very High Very High
noradrenaline 8 91.68 High High
Dopamine 6 89.12 High High
medulla 6 62.48 Quite High
Enkephalin 3 28.32 Quite Low
Somatostatin 4 27.28 Quite Low
imagery 37 8.28 Low Low
tricyclic antidepressant 2 8.16 Low Low
Disease Link Frequency Relevance Heat
Paraganglioma 131 100.00 Very High Very High Very High
Pheochromocytoma 105 100.00 Very High Very High Very High
Watson Syndrome 12 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 6 100.00 Very High Very High Very High
Von Hippel-lindau Syndrome 4 100.00 Very High Very High Very High
Disease 42 99.82 Very High Very High Very High
Hypertension 29 98.96 Very High Very High Very High
Headache 7 97.32 Very High Very High Very High
Cancer 129 96.92 Very High Very High Very High
Heart Rate Under Development 16 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical investigation for PH/PGL is generally confined to hypertensive patients reporting bouts of headaches, palpitations and sweating, those with hypertension resistant to treatment, and those with incidentalomas or with a familial disease that predisposes to PH and/or PGL.
PGL Binding (investigation) of associated with heart rate under development, hypertension, paraganglioma, headache, disease and pheochromocytoma
1) Confidence 0.37 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.56 Pain Relevance 0.53
Presymptomatic diagnosis is also possible in patients with phenotypic evidence or a family history of a genetic disease that is associated with PH/PGL (see below).


PGL Binding (associated) of associated with paraganglioma, disease and pheochromocytoma
2) Confidence 0.35 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.89 Pain Relevance 0.10
Paragangliomas may be hereditary and can be associated with familial paraganglioma, neurofibromatosis type 1, von Hippel-Lindau disease, the Carney triad, multiple endocrine neoplasia type 2, and mutations of the succinate dehydrogenase genes (SDHB, SDHC, and SDHD) [1].
SDHD Binding (associated) of associated with multiple endocrine neoplasia type 2a, von hippel-lindau syndrome, paraganglioma and watson syndrome
3) Confidence 0.24 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 1.06 Pain Relevance 0.08

General Comments

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