INT200217

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 15.51
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAH) small molecule metabolic process (PAH) cellular nitrogen compound metabolic process (PAH)
Anatomy Link Frequency
blood 1
plasma 1
lung 1
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 32 99.96 Very High Very High Very High
Catecholamine 242 98.60 Very High Very High Very High
withdrawal 1 98.28 Very High Very High Very High
Dopamine 24 97.20 Very High Very High Very High
Serotonin 1 95.40 Very High Very High Very High
medulla 16 95.28 Very High Very High Very High
headache 25 92.36 High High
Neuropeptide 16 91.04 High High
Catechol-O-methyltransferase 8 85.44 High High
metalloproteinase 3 83.84 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 400 100.00 Very High Very High Very High
Pressure And Volume Under Development 122 100.00 Very High Very High Very High
Pulmonary Hypertension 65 100.00 Very High Very High Very High
Stress 28 100.00 Very High Very High Very High
Paraganglioma 384 99.96 Very High Very High Very High
Death 2 99.96 Very High Very High Very High
Cancer 427 99.68 Very High Very High Very High
Disease 177 98.74 Very High Very High Very High
Edema 8 97.72 Very High Very High Very High
Hypertension 151 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with von Hippel Lindau (VHL) disease or familial PGL (see below) may have uni- or bilateral PH, or PH plus secreting or non-secreting PGL [1,2].


Localization (secreting) of PH associated with paraganglioma, disease and pheochromocytoma
1) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.83 Pain Relevance 0.35
The diagnosis of PH or secreting PGL is excluded in these cases by the normalization of metanephrines ten days after the onset of the event [14].
Localization (secreting) of PH associated with paraganglioma and pheochromocytoma
2) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.97 Pain Relevance 0.25
Positive diagnosis of PH and secreting PGL is chiefly based on the quantification of plasma or urinary metanephrines, as this test is more sensitive than both the quantification of urinary vanillyl-mandelate acid or plasma catecholamines [2,3,14-16], and plasma neuropeptide Y or chromogranin A determinations [17,18].
Localization (secreting) of PH in plasma associated with catecholamine, neuropeptide, paraganglioma and pheochromocytoma
3) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.50 Pain Relevance 0.59
The mechanism of this increase in resistance would seem to be straightforward because noradrenaline, secreted by the majority of PH, is a potent vasoconstrictor through stimulation of ?
Localization (secreted) of PH associated with noradrenaline and pheochromocytoma
4) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.01 Pain Relevance 0.29
The etiology of tumorigenesis in PH and secreting PGL is unknown, although valuable information has recently been provided by work on the genomics of familial diseases including these tumors.
Localization (secreting) of PH associated with cancer, paraganglioma, disease and pheochromocytoma
5) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.89 Pain Relevance 0.07
Ten percent of catecholamine-producing tumors arise from extraadrenal chromaffin tissue and are called extraadrenal PH or secreting paragangliomas (PGL).
Localization (secreting) of PH associated with cancer, catecholamine, paraganglioma and pheochromocytoma
6) Confidence 0.36 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.62 Pain Relevance 0.17
Genetic testing is indicated for all patients with PGL and/or PH, whatever the location of the tumor and the age of the subjects, but such testing may also be indicated by clinical and familial features (Figure 1).
Localization (location) of PH associated with cancer, paraganglioma and pheochromocytoma
7) Confidence 0.34 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.50 Pain Relevance 0.03
PH and secreting PGL are defined by the synthesis and/or secretion of catecholamines: dopamine, norepinephrine and/or epinephrine.
Localization (secreting) of PH associated with dopamine, catecholamine, paraganglioma and pheochromocytoma
8) Confidence 0.32 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.86 Pain Relevance 0.37
In ARIES-2, patients treated with ambrisentan had a longer time before clinical worsening, a composite endpoint defined as death, hospitalization for PAH, lung transplantation, atrial septostomy, withdrawal from the study to initiate therapy with other PAH medications, or early escape criteria (Figure 3) (p < 0.001 for both ambrisentan doses combined versus placebo).
Localization (hospitalization) of PAH in lung associated with pulmonary hypertension, withdrawal and death
9) Confidence 0.26 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.57 Pain Relevance 0.05
Therefore, the substances which are released by the stress systems in the blood during PH, that is, aldosterone, renin, and catecholamines, will accumulate selectively in the splanchnic interstitial space because of an increased endothelial permeability [1].
Localization (released) of PH in blood associated with stress, pressure and volume under development and catecholamine
10) Confidence 0.04 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 0.76 Pain Relevance 0.28

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