INT200219

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 15.38
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VHL) mitochondrion (VHL) cell morphogenesis (VHL)
endoplasmic reticulum (VHL) nucleus (VHL) extracellular matrix organization (VHL)
Anatomy Link Frequency
germline 3
ventricle 1
proximal 1
heart 1
VHL (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 80.80 Quite High
Analgesic 5 75.52 Quite High
Paracetamol 4 74.68 Quite High
aspirin 2 71.00 Quite High
Angina 12 66.16 Quite High
noradrenaline 4 62.48 Quite High
imagery 45 55.20 Quite High
Catecholamine 30 51.04 Quite High
Restless leg syndrome 1 42.08 Quite Low
adenocard 9 34.32 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 66 100.00 Very High Very High Very High
Disease 449 99.98 Very High Very High Very High
Cancer 633 99.96 Very High Very High Very High
Renal Cancer 492 99.92 Very High Very High Very High
Syndrome 390 99.08 Very High Very High Very High
Pheochromocytoma 115 97.76 Very High Very High Very High
Pathologic Constriction 30 96.00 Very High Very High Very High
Hemangioma 8 95.72 Very High Very High Very High
Hemangioblastoma 16 95.04 Very High Very High Very High
Carcinoma 38 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another class of VHL point mutations inactivates pVHL
Positive_regulation (inactivates) of pVHL
1) Confidence 0.50 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.47 Pain Relevance 0
or clear cell RCC, who have no detectable VHL disease-causing germline mutation; somatic mosaicism for a VHL gene mutation still needs to be considered in
Positive_regulation (needs) of VHL in germline associated with disease
2) Confidence 0.50 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.17 Pain Relevance 0
associated microtubule-stabilizing function of pVHL, implicating defective
Positive_regulation (stabilizing) of pVHL
3) Confidence 0.50 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.59 Pain Relevance 0
inactivation of the von Hippel Lindau (VHL) tumor
Positive_regulation (inactivation) of VHL associated with cancer
4) Confidence 0.49 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2467459 Disease Relevance 1.05 Pain Relevance 0.03
the proband are at 50% risk of inheriting the altered gene; and if neither parent has the disease-causing VHL mutation identified in the proband, the sibs have a small risk of VHL syndrome because of
Positive_regulation (causing) of VHL associated with syndrome and disease
5) Confidence 0.47 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.67 Pain Relevance 0
physicians ordering VHL molecular genetic testing and individuals
Positive_regulation (ordering) of VHL
6) Confidence 0.44 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.52 Pain Relevance 0
inheriting the mutant VHL gene; but the degree of clinical severity is
Positive_regulation (inheriting) of VHL
7) Confidence 0.44 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.66 Pain Relevance 0
Genetically, VHL is caused
Positive_regulation (caused) of VHL
8) Confidence 0.41 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.24 Pain Relevance 0
who do not have a detectable VHL germline mutation, somatic mosaicism
Neg (not) Positive_regulation (have) of VHL in germline
9) Confidence 0.41 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.73 Pain Relevance 0
subunits activated by either inactivation of VHL or hypoxia heterodimerize with a constitutively available HIF1?
Positive_regulation (inactivation) of VHL associated with hypoxia
10) Confidence 0.34 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.60 Pain Relevance 0
The LM, LAD, proximal and mid segments of the Cx, RDP and proximal segment of RCA showed laminar flow and normal flow velocities, without any signs of colour-aliasing suggestive of stenosis.
Positive_regulation (segments) of RCA in proximal associated with pathologic constriction
11) Confidence 0.32 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2100043 Disease Relevance 0.37 Pain Relevance 0.15
the von Hippel-Lindau tumor suppressor protein

(pVHL) in renal cell carcinoma cells. pVHL is often inactivated in renal cell

Positive_regulation (inactivated) of pVHL associated with cancer and renal cancer
12) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.63 Pain Relevance 0
Activation of the hypoxia response pathway by mutations of the von Hippel-Lindau (VHL) tumor suppressor gene produces transcriptional activation of genes important in tumor progression, including vascular endothelial growth factor (VEGF), a potent promoter of tumor-associated angiogenesis.2,7 The VHL gene encodes a 213 amino acid protein (pVHL) which functionally regulates the normal cellular response to oxygen deprivation.
Positive_regulation (Activation) of VHL associated with cancer and hypoxia
13) Confidence 0.31 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.34 Pain Relevance 0
VHL gene mutations
Positive_regulation (mutations) of VHL
14) Confidence 0.30 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.28 Pain Relevance 0
A frequent genetic alteration in both hereditary and sporadic RCC is mutation of VHL, which encodes the targeting subunit of another ubiquitin ligase complex responsible for degrading hypoxia inducible factors, HIF1/2 alpha.
Positive_regulation (mutation) of VHL associated with hypoxia and renal cancer
15) Confidence 0.30 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.90 Pain Relevance 0
caused by germline mutations of the VHL tumor suppressor gene, located on
Positive_regulation (mutations) of VHL in germline associated with cancer
16) Confidence 0.24 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.41 Pain Relevance 0.44
In the absence of pVHL, HIF becomes stabilized and is free to induce the expression of several target genes that regulate angiogenesis and cell growth [12].
Positive_regulation (stabilized) of pVHL
17) Confidence 0.20 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.26 Pain Relevance 0.06
Hemodynamic variables including heart rate (HR), MAP, central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), PCWP, cardiac index (CI), mixed venous oxygen saturation (SvO2), RV end diastolic volume index (RVEDVI), and RVEF were recorded 15 min after returning the heart to its natural position following completion of grafting at the left coronary arteries before RCA grafting (baseline, T1), 10 min after application of tissue stabilizer for distal anastomosis of the RCA (T2), and 15 min after completion of RCA grafting with the heart in its natural position (T3).
Positive_regulation (stabilizer) of RCA in heart
18) Confidence 0.11 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526513 Disease Relevance 0.08 Pain Relevance 0
LAD continued across the left ventricular apex as posterior descending artery (PDA), running along the posterior interventricular septum up to the atrioventricular groove, where it gave off the left ventricular branch to the inferior surface of left ventricle and thereafter continued as the distal RCA without establishing any communication with the atretic proximal RCA (Fig 5).
Positive_regulation (proximal) of RCA in ventricle
19) Confidence 0.10 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC2104526 Disease Relevance 0.40 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox