INT200223

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 21.95
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1) signal transduction (EPAS1) mitochondrion organization (EPAS1)
nucleus (EPAS1) DNA binding (EPAS1) transcription factor binding (EPAS1)
Anatomy Link Frequency
tendon 2
endothelial cells 1
EPAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 99.96 Very High Very High Very High
Arthritis 128 98.86 Very High Very High Very High
Bioavailability 2 86.32 High High
Inflammation 242 85.80 High High
rheumatoid arthritis 45 85.52 High High
noradrenaline 8 84.96 Quite High
chemokine 72 75.88 Quite High
Catecholamine 60 73.52 Quite High
antagonist 29 71.68 Quite High
Osteoarthritis 45 60.40 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 244 100.00 Very High Very High Very High
Tendinopathy 12 99.96 Very High Very High Very High
Hepatitis 10 99.76 Very High Very High Very High
Respiratory Syncytial Virus 495 99.68 Very High Very High Very High
Disease 208 99.62 Very High Very High Very High
Infection 448 99.52 Very High Very High Very High
Cancer 531 99.32 Very High Very High Very High
Rotator Cuff Tears 120 99.32 Very High Very High Very High
Renal Cell Carcinoma 29 99.28 Very High Very High Very High
Hypertension 37 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further histological studies are required to investigate the mechanism of this finding; HIF and VEGF upregulation may help to explain these observations.
Positive_regulation (upregulation) of HIF
1) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 1.08 Pain Relevance 0.03
However, there is evidence that HIF can also be induced under normal conditions by growth factors, hormones or nitric oxide [35].
Positive_regulation (induced) of HIF
2) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.49 Pain Relevance 0
HIF, which is induced by cell hypoxia, is one of the most important regulators of VEGF gene expression [28].
Positive_regulation (induced) of HIF associated with hypoxia
3) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 1.10 Pain Relevance 0.04
Since HIF induction was initially described in conditions of decreased oxygen partial pressure, the majority of studies on HIF regulation have addressed hypoxic conditions [34].
Positive_regulation (induction) of HIF associated with hypoxia
4) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.80 Pain Relevance 0.03
Lewis et al. described increased neovascularity in patients with rotator cuff tendinopathy; increased HIF and VEGF expression in the diseased rotator cuff, but not in tendon retraction [12].
Positive_regulation (increased) of HIF in tendon associated with tendinopathy
5) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.70 Pain Relevance 0
Their unique action is attributed to their effect directly on the tumor cells themselves, in part due to HIF downregulation, and on tumor endothelial cells by blocking proliferation and survival signals downstream of the VEGF receptor.23–25 One study has also shown that the benefits of mTOR inhibition may be greater in papillary renal carcinoma than in clear cell carcinoma; papillary subtype accounting for 10% to 15% of renal cell cancers.26 This is postulated to be due to HIF upregulation which is noted in patients with papillary renal cell carcinoma associated with fumarate–hydratase mutations.27
Positive_regulation (upregulation) of HIF in endothelial cells associated with cancer, carcinoma and renal cell carcinoma
6) Confidence 0.12 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.93 Pain Relevance 0
We showed that HIF and VEGF are upregulated in full-thickness rotator cuff tears (highest in group IV, Patte stage1 III), leading to higher vessel density while angiogenetic peptides are not detected in healthy tendon.
Positive_regulation (upregulated) of HIF in tendon associated with rotator cuff tears
7) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.45 Pain Relevance 0
When SDH is inhibited, the accumulation of succinate seems to inhibit the prolyl-hydroxylation of HIF and induce, as in VHL disease, an inappropriate stabilization of HIF [13].
Positive_regulation (stabilization) of HIF associated with disease
8) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 0.99 Pain Relevance 0.16
Tumours respond to low oxygen tension by enhancing the hypoxia-inducible factor (HIF) response [27].
Positive_regulation (enhancing) of hypoxia-inducible factor associated with hypoxia and cancer
9) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.91 Pain Relevance 0
Tumours respond to low oxygen tension by enhancing the hypoxia-inducible factor (HIF) response [27].
Positive_regulation (enhancing) of HIF associated with hypoxia and cancer
10) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.91 Pain Relevance 0
In the absence of pVHL, HIF becomes stabilized and is free to induce the expression of several target genes that regulate angiogenesis and cell growth [12].
Positive_regulation (stabilized) of HIF
11) Confidence 0.05 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.26 Pain Relevance 0.06
Hypoxic conditions also increase the activity of hypoxia-inducible factor (HIF-1?)
Positive_regulation (increase) of hypoxia-inducible factor associated with hypoxia
12) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.76 Pain Relevance 0.04
Hypoxia acts through the hypoxia-inducible factor heterodimer, HIF-1?
Positive_regulation (acts) of hypoxia-inducible factor associated with hypoxia
13) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.92 Pain Relevance 0.23
While HIF is classically activated posttranscriptionally, these studies demonstrate that both alpha-subunits are up-regulated at the transcript level by KSHV infection.
Positive_regulation (activated) of HIF associated with infection
14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.25 Pain Relevance 0
Here, the transcriptional activation of HIF leads to a functional increase in HIF activity under normoxic conditions, as shown utilizing luciferase reporter assays and HIF-dependent gene expression.
Positive_regulation (increase) of HIF
15) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.33 Pain Relevance 0.03
In RA, a severely hypoxic environment and possibly cytokines, induce Hif (hypoxia inducible factor) mediated transcriptional activation of VEGF and many other pro-angiogenic genes [10], [26], [27], [37].
Positive_regulation (induce) of Hif associated with hypoxia, cytokine and arthritis
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.79 Pain Relevance 0.27
In RA, a severely hypoxic environment and possibly cytokines, induce Hif (hypoxia inducible factor) mediated transcriptional activation of VEGF and many other pro-angiogenic genes [10], [26], [27], [37].
Positive_regulation (inducible) of Hif associated with hypoxia, cytokine and arthritis
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.80 Pain Relevance 0.27
In RA, a severely hypoxic environment and possibly cytokines, induce Hif (hypoxia inducible factor) mediated transcriptional activation of VEGF and many other pro-angiogenic genes [10], [26], [27], [37].
Positive_regulation (activation) of Hif associated with hypoxia, cytokine and arthritis
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.87 Pain Relevance 0.28
For example, previous studies have suggested a functional role of the hepatitis C virus in HIF stabilization [33].
Positive_regulation (stabilization) of HIF associated with hepatitis
19) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.85 Pain Relevance 0.08
, suggesting concomitant HIF-activation during RSV infection.
Positive_regulation (activation) of HIF associated with infection and respiratory syncytial virus
20) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556398 Disease Relevance 1.81 Pain Relevance 0.08

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