INT200250

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.97
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac2) enzyme binding (Hdac2) transcription factor binding (Hdac2)
cytoplasm (Hdac2)
Anatomy Link Frequency
lungs 1
NS20Y 1
Hdac2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 266 99.68 Very High Very High Very High
Inflammatory response 77 92.44 High High
mu opioid receptor 160 92.32 High High
cytokine 30 85.04 High High
dexamethasone 8 52.00 Quite High
corticosteroid 5 38.72 Quite Low
Bioavailability 11 20.84 Low Low
chemokine 26 5.00 Very Low Very Low Very Low
metalloproteinase 22 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 69 99.82 Very High Very High Very High
INFLAMMATION 353 99.68 Very High Very High Very High
Disease 157 99.42 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 324 98.82 Very High Very High Very High
Repression 36 98.48 Very High Very High Very High
Nicotine Addiction 79 93.56 High High
Solid Tumor 21 92.88 High High
Breast Cancer 4 83.80 Quite High
Cancer 66 77.20 Quite High
Lymphatic System Cancer 22 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Sp1 mainly acts as transcriptional activator, Sp3 can repress activity of the promoter by recruiting HDAC1 or HDAC2.
HDAC2 Binding (recruiting) of
1) Confidence 0.22 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.11
After cross-linking the proteins and DNAs with formaldehyde, cell lysates from NS20Y cells were subjected to immunoprecipitation with NRSF, HDAC1, HDAC2, Sp1, Sp3 and IRF-4 (as a negative control).
HDAC2 Binding (immunoprecipitation) of in NS20Y
2) Confidence 0.22 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.25
The acetylation levels correlated with VPA serum levels and could be linked to baseline HDAC2—but not HDAC6 expression.
HDAC2 Binding (linked) of
3) Confidence 0.17 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.71 Pain Relevance 0
Glucocorticoid suppression of inflammatory genes requires recruitment of HDAC2 to the transcription activation complex by the glucocorticoid receptor (Ito et al 2001; Rahman et al 2004).
HDAC2 Binding (recruitment) of associated with inflammation
4) Confidence 0.15 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.56 Pain Relevance 0.27
Acutely, oxidative stress reduces HDAC-2 activity with a reduction in HDAC-2 protein expression seen with more chronic oxidant exposures in in vitro and in vivo models.71,78,79 This reduction in HDAC-2 activity and expression is strongly associated with oxidant-mediated covalent modifications, including hyperphosphorylation, nitration, and carbonylation, which impair protein activity and enhance proteasomal degradation.72,73,78–83 These modifications are mediated by reactive oxygen, including reactive carbonyls and reactive nitrogen species, and by kinase signaling pathways activated by oxidant stress.72,73,83 Although the exact mechanisms and pathways that regulate these modifications remain unclear, recent work has suggested that oxidants modulate HDAC-2 phosphorylation and subsequent ubiquitination followed by proteasomal degradation through a protein kinase CK2?
HDAC-2 Spec (unclear) Binding (activity) of associated with stress
5) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.52 Pain Relevance 0.03
protects GC function appears to be mediated through the protection of HDAC-2 activity, it is also likely to include modulation of other corepressors, such as Mi-2 and mSin3a.55,97 The mechanism by which PI3K?
HDAC-2 Binding (activity) of
6) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.68 Pain Relevance 0.05
In agreement with this, HDAC-2 activity and expression are reduced in the peripheral lungs of patients with COPD, which correlate with disease severity.86 Furthermore, as HDAC-2 activity is fundamental for functional GR?
HDAC-2 Binding (activity) of in lungs associated with chronic obstructive pulmonary disease and disease
7) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.51 Pain Relevance 0.05

General Comments

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