INT200258

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf4) DNA binding (Irf4) cytoplasm (Irf4)
Anatomy Link Frequency
NS20Y 1
Irf4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 99.76 Very High Very High Very High
mu opioid receptor 80 92.32 High High
rheumatoid arthritis 5 51.68 Quite High
corticosteroid 1 14.88 Low Low
cINOD 1 12.16 Low Low
Inflammation 16 6.32 Low Low
Morphine 3 5.00 Very Low Very Low Very Low
opioid receptor 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 23 91.92 High High
Necrosis 2 82.32 Quite High
Cancer 4 81.96 Quite High
Diabetes Mellitus 3 52.48 Quite High
Rheumatoid Arthritis 5 51.68 Quite High
Repression 14 50.00 Quite Low
Systemic Lupus Erythematosus 61 49.60 Quite Low
Disease 20 29.52 Quite Low
INFLAMMATION 16 11.76 Low Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By IRF4 competing with IRF5 for binding, it inhibits the activation of IRF5 thus impairing IRF5-mediated cytokine production.

3.

IRF4 Binding (binding) of associated with cytokine
1) Confidence 0.21 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.43 Pain Relevance 0.18
After cross-linking the proteins and DNAs with formaldehyde, cell lysates from NS20Y cells were subjected to immunoprecipitation with NRSF, HDAC1, HDAC2, Sp1, Sp3 and IRF-4 (as a negative control).
IRF-4 Binding (immunoprecipitation) of in NS20Y
2) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.25

General Comments

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