INT200264

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp3) intracellular (Sp3) DNA binding (Sp3)
Anatomy Link Frequency
NS20Y 1
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 320 99.84 Very High Very High Very High
Morphine 12 5.00 Very Low Very Low Very Low
opioid receptor 12 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 56 50.00 Quite Low
Disease 16 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The subtle shift in mobility (lane 7) or no apparent mobility shift (land 8) may be due to the presence of various nuclear proteins that were recruited by both NRSF and Sp3 and/or due to the binding of other nuclear proteins which have affinity for the probe DNA sequences that could now be available after the displacement of NRSF or Sp3 by the mutated competitors.
Localization (recruited) of Sp3
1) Confidence 0.62 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.03
The two lower complexes were not affected (lanes 5 and 6) by both antibodies, suggesting that these are not related to NRSF or Sp3.
Neg (not) Localization (related) of Sp3
2) Confidence 0.62 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.07
In vitro translation of NRSF and Sp3 was performed using the TNT SP6 and T7 Quick Coupled Transcription/Translation System as per the manufacturer's protocol (Promega) and nuclear extracts from NS20Y cells were prepared as described previously (11).
Localization (translation) of Sp3 in NS20Y
3) Confidence 0.62 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.04
In addition, we performed the Re-ChIP assay to verify the Sp3 and NRSF are specifically co-localized on MOR DNA (Figure 7C).
Localization (localized) of Sp3 associated with mu opioid receptor
4) Confidence 0.58 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.33

General Comments

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