INT200265

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.25
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp3) intracellular (Sp3) DNA binding (Sp3)
Anatomy Link Frequency
internal 1
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 80 99.48 Very High Very High Very High
anesthesia 27 91.92 High High
cytokine 13 44.12 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Morphine 3 5.00 Very Low Very Low Very Low
opioid receptor 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 12 89.84 High High
Obesity 2 55.28 Quite High
Repression 14 52.60 Quite High
Alzheimer's Dementia 40 45.92 Quite Low
Creutzfeldt Jakob Disease 25 40.64 Quite Low
Disease 25 28.52 Quite Low
Disorder Of Lipid Metabolism 2 26.56 Quite Low
Atherosclerosis 11 25.84 Quite Low
Targeted Disruption 25 20.16 Low Low
Neurodegenerative Disease 1 14.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because two short isoforms are generated by internal start codon, it can be speculated that the N-terminal region (112 amino acid residues) of Sp3, which is absent from the two short isoforms, takes responsibility for the interaction of the full-length Sp3 with NRSF and for determining the role of Sp3 factors for MOR gene expression.
Spec (determining) Regulation (role) of Sp3 in internal associated with mu opioid receptor
1) Confidence 0.37 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.05 Pain Relevance 0.16
The CK2- and PI3K-mediated regulation of Sp1/Sp3 binding could represent one such mechanism.


Regulation (regulation) of Sp1/Sp3
2) Confidence 0.30 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.06 Pain Relevance 0
We wished to determine whether the protease sensitivity and ASA activity of MoSP2, MoSP3, and MoSP4 were maintained upon serial passage in Tg9949 mice.
Spec (whether) Regulation (sensitivity) of MoSP3
3) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2809756 Disease Relevance 0.14 Pain Relevance 0.18

General Comments

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