INT200266

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.73
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ahrr) nucleus (Ahrr) DNA binding (Ahrr)
cytoplasm (Ahrr) signal transducer activity (Ahrr)
Anatomy Link Frequency
neuronal 3
NAc 1
Ahrr (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 52 99.80 Very High Very High Very High
mu opioid receptor 160 94.60 High High
Enkephalin 1 89.88 High High
gABA 2 89.24 High High
Somatostatin 1 89.04 High High
opioid receptor 6 72.04 Quite High
orphanin 2 71.52 Quite High
Calcium channel 1 63.12 Quite High
long-term potentiation 1 60.64 Quite High
Morphine 6 57.28 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 46 96.00 Very High Very High Very High
Cold Sores 1 81.44 Quite High
Herpes Simplex Virus 2 81.24 Quite High
Targeted Disruption 35 75.36 Quite High
Sprains And Strains 1 65.60 Quite High
Congenital Anomalies 3 63.04 Quite High
Repression 30 50.00 Quite Low
Convulsion 10 38.16 Quite Low
Cognitive Disorder 1 26.08 Quite Low
Stress 12 15.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Being an inducible and powerful repressor of cAMP-dependent transcription, ICER can potentially affect the expression of numerous CRE-containing genes, including genes whose products are critically involved in neuronal plasticity; genes that encode transcription factors (c-fos, JunD, Krox-20, Krox-24, creb, icer); genes that encode neurotransmission-related proteins (enkephalin, galanin, somatostatin, CRH, tyrosine hydroxylase, GABAA receptor subunits, ?
Gene_expression (expression) of repressor in neuronal associated with somatostatin and enkephalin
1) Confidence 0.01 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.16 Pain Relevance 0.26
In line with these findings, NAc-specific expression of the inducible cAMP early repressor (ICER), a natural inhibitor of CREB-mediated transcription, has been shown to increase measures of anxiety in the elevated plus maze and neophobia to novel tastes [11].
Gene_expression (expression) of early repressor in NAc associated with nucleus accumbens and anxiety disorder
2) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.57 Pain Relevance 0.21
In both non-neuronal and neuronal cells, NRSF silences the expression of its target genes by its two independently acting repressor domains (12,13).
Gene_expression (expression) of repressor in neuronal
3) Confidence 0.01 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.41
In both non-neuronal and neuronal cells, NRSF silences the expression of its target genes by its two independently acting repressor domains (12,13).
Gene_expression (expression) of repressor in neuronal
4) Confidence 0.00 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox