INT200272

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.06
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
macrophages 1
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 164 99.40 Very High Very High Very High
opioid receptor 8 90.44 High High
agonist 1 63.64 Quite High
opiate 1 63.28 Quite High
cytokine 13 61.04 Quite High
Morphine 5 58.96 Quite High
analgesia 1 52.80 Quite High
Opioid 2 50.88 Quite High
Endogenous opioid 1 49.92 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 61.28 Quite High
Repression 22 50.00 Quite Low
Contagious Ecthyma 14 34.80 Quite Low
Atherosclerosis 11 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 7C, Sp3, but not Sp1 and NRSF are specifically co-localized on the 188 bp MOR promoter sequence containing NRSE and a GC box.
Localization (localized) of Sp1 associated with mu opioid receptor
1) Confidence 0.57 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.30
Our laboratory and others have demonstrated that MOR promoter activity is regulated by many enhancer elements and their related transcriptional factors such as SOX, SP1, AP2, NF-?
Localization (related) of SP1 associated with mu opioid receptor
2) Confidence 0.41 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.06 Pain Relevance 0.60
Thus, Sp1 or STAT1 was immunoprecipitated from extracts of J774.2 macrophages that had either been left untreated or stimulated with IFN-?
Localization (immunoprecipitated) of Sp1 in macrophages
3) Confidence 0.40 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

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