INT200275

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rest) nucleus (Rest) intracellular (Rest)
DNA binding (Rest) protein complex (Rest) transcription factor binding (Rest)
Anatomy Link Frequency
neuronal 4
Rest (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 160 63.52 Quite High
opioid receptor 6 30.76 Quite Low
Morphine 6 16.00 Low Low
Analgesic 2 15.08 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 100.00 Very High Very High Very High
Repression 28 99.08 Very High Very High Very High
Disease 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, overexpression of the dominant-negative NRSF and knock-out of NRSF failed to release the repression of its target gene completely, even though NRSF was originally defined as a repressor for neuronal-specific gene in non-neuronal cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NRSF in neuronal associated with targeted disruption and repression
1) Confidence 0.59 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.46 Pain Relevance 0.08
In addition, overexpression of the dominant-negative NRSF and knock-out of NRSF failed to release the repression of its target gene completely, even though NRSF was originally defined as a repressor for neuronal-specific gene in non-neuronal cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NRSF in neuronal associated with targeted disruption and repression
2) Confidence 0.37 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.46 Pain Relevance 0.08

General Comments

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