INT200278

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.08
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Preb) vesicle-mediated transport (Preb) endoplasmic reticulum (Preb)
nucleus (Preb) DNA binding (Preb)
Anatomy Link Frequency
neurons 5
Preb (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 80 100.00 Very High Very High Very High
medulla 75 96.68 Very High Very High Very High
gABA 45 85.92 High High
Action potential 35 66.60 Quite High
tetrodotoxin 10 62.16 Quite High
GABAergic 5 43.48 Quite Low
Central nervous system 16 15.12 Low Low
Neurotransmitter 20 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 81.44 Quite High
Death 25 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Fasciculation 10 5.00 Very Low Very Low Very Low
Respiratory Failure 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Cyanosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ultra-structural analysis of synapses of preBötC neurons reveals no changes in TGF-?
Gene_expression (neurons) of preB in neurons
1) Confidence 0.51 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04
In contrast, both the frequency and amplitude of sIPSCs in preBötC neurons were decreased in TGF-?
Gene_expression (neurons) of preB in neurons
2) Confidence 0.51 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.17
Severe impairment of network activity and synaptic transmission in preBötC neurons in TGF-?
Gene_expression (neurons) of preB in neurons
3) Confidence 0.51 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.15
Immunohistochemistry and light microscopic quantification of synapses of preBötC neurons
Gene_expression (synapses) of preB in neurons
4) Confidence 0.44 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0
We found that both the frequency and amplitude of sPSCs in preBötC neurons were largely diminished in TGF-?
Gene_expression (neurons) of preB in neurons
5) Confidence 0.44 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.11
Therefore, the negative effect of the putative Sp-binding element for the MOR gene expression could be considered as additive to or preferably synergic with NRSE.
Gene_expression (expression) of Sp-binding element associated with mu opioid receptor
6) Confidence 0.02 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.08 Pain Relevance 0.40

General Comments

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