INT20028

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.52
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
neurons 4
pituitary 4
somatotroph 2
respiratory 2
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 18 100.00 Very High Very High Very High
withdrawal 8 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
agonist 4 99.92 Very High Very High Very High
Clonidine 17 95.88 Very High Very High Very High
Somatostatin 8 84.64 Quite High
Analgesic 1 82.32 Quite High
opiate 3 71.36 Quite High
antagonist 2 70.80 Quite High
narcan 2 69.92 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 100.00 Very High Very High Very High
Bacterial Infection 2 99.72 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

5 89.44 High High
Overdose 1 87.88 High High
Endotoxemia 1 86.32 High High
Growth Hormone Deficiency 3 75.00 Quite High
Aging 33 64.16 Quite High
Hypopituitarism 2 57.24 Quite High
Growth Problems 2 45.12 Quite Low
Vibrio Infection 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of the GH releasing hormone (GHRH) induced pronounced GH secretion in reserpine pretreated animals of both sexes; this effect was not significantly affected by gonadectomy.
Positive_regulation (Administration) of Gene_expression (Administration) of GH releasing hormone
1) Confidence 0.50 Published 1988 Journal J. Neural Transm. Section Abstract Doc Link 3126262 Disease Relevance 0 Pain Relevance 0.46
Administration of the GH releasing hormone (GHRH) induced pronounced GH secretion in reserpine pretreated animals of both sexes; this effect was not significantly affected by gonadectomy.
Positive_regulation (Administration) of Gene_expression (Administration) of GHRH
2) Confidence 0.50 Published 1988 Journal J. Neural Transm. Section Abstract Doc Link 3126262 Disease Relevance 0 Pain Relevance 0.46
In conclusion, in slowly growing children PD + GHRH test is the most reliable provocative test for the diagnosis of primary pituitary GH deficiency being capable to discriminate between an unequivocally normal and impaired somatotropic function.
Positive_regulation (provocative) of Gene_expression (growing) of GHRH in pituitary
3) Confidence 0.32 Published 1990 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2115060 Disease Relevance 0.07 Pain Relevance 0.17
In conclusion, in slowly growing children PD + GHRH test is the most reliable provocative test for the diagnosis of primary pituitary GH deficiency being capable to discriminate between an unequivocally normal and impaired somatotropic function.
Positive_regulation (provocative) of Gene_expression (test) of GHRH in pituitary
4) Confidence 0.32 Published 1990 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2115060 Disease Relevance 0.07 Pain Relevance 0.17
In conscious rats subjected to endotoxic shock, thyrotropin releasing hormone (TRH) is shown to produce a rapid increase in cardiovascular variables and respiratory rates at intravenous doses between 0.20 and 6.34 mg/kg.
Positive_regulation (increase) of Gene_expression (produce) of releasing hormone in respiratory associated with bacterial infection
5) Confidence 0.24 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6797829 Disease Relevance 0.26 Pain Relevance 0.22
Glucocorticoids (GCs) play a key role in the physiology of the hypothalamic-somatotroph axis, since these steroids enhance growth hormone (GH) gene transcription and increase GHRH receptor synthesis.
Positive_regulation (increase) of Gene_expression (synthesis) of GHRH in somatotroph
6) Confidence 0.15 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.04
Once daily GHRH injections can stimulate increases in GH and IGF-I at least to the lower part of the young adult normal range (Merriam et al 2000).
Positive_regulation (stimulate) of Gene_expression (injections) of GHRH
7) Confidence 0.11 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.21 Pain Relevance 0.04
Our previous study has shown that prothyrotropin-releasing hormone (proTRH) gene expression is increased in the ventrolateral periaqueductal gray (PAG) neurons following precipitated morphine withdrawal and continues to be activated even 24 h after withdrawal.
Positive_regulation (activated) of Gene_expression (expression) of prothyrotropin-releasing hormone in neurons associated with withdrawal, central grey and morphine
8) Confidence 0.02 Published 2001 Journal Brain Res. Section Abstract Doc Link 11701131 Disease Relevance 0.42 Pain Relevance 0.54
Our previous study has shown that prothyrotropin-releasing hormone (proTRH) gene expression is increased in the ventrolateral periaqueductal gray (PAG) neurons following precipitated morphine withdrawal and continues to be activated even 24 h after withdrawal.
Positive_regulation (increased) of Gene_expression (expression) of prothyrotropin-releasing hormone in neurons associated with withdrawal, central grey and morphine
9) Confidence 0.02 Published 2001 Journal Brain Res. Section Abstract Doc Link 11701131 Disease Relevance 0.39 Pain Relevance 0.51

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