INT200307

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rest, Rorb) intracellular (Rest) DNA binding (Rest)
protein complex (Rest) cytoplasm (Rest) cytosol (Rest)
Anatomy Link Frequency
neuronal 1
neuron 1
Rest (Mus musculus)
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 160 100.00 Very High Very High Very High
opioid receptor 6 81.20 Quite High
Morphine 6 66.44 Quite High
Analgesic 2 65.52 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 28 98.56 Very High Very High Very High
Disease 8 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also reported that MOR transcription is suppressed by the neuron-restrictive silencer element (NRSE) in the mouse MOR promoter through binding of neuron-restriction silence factor (NRSF) (11).
neuron-restrictive silencer element Negative_regulation (suppressed) of transcription in neuron associated with mu opioid receptor
1) Confidence 0.00 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.64
Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene

Previously, we reported that the neuron-restrictive silencer element (NRSE) of mu opioid receptor (MOR) functions as a critical regulator to repress the MOR transcription in specific neuronal cells, depending on neuron-restriction silence factor (NRSF) expression levels [C.S.Kim, C.K.Hwang, H.S.Choi, K.Y.Song, P.Y.Law, L.N.Wei and H.H.Loh (2004) J.

neuron-restrictive silencer element Negative_regulation (repress) of transcription in neuronal associated with repression and mu opioid receptor
2) Confidence 0.00 Published 2006 Journal Nucleic Acids Research Section Title Doc Link PMC1702488 Disease Relevance 0.10 Pain Relevance 0.40

General Comments

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