INT200309

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rest, Sp3) intracellular (Rest, Sp3) DNA binding (Rest, Sp3)
cytosol (Rest) protein complex (Rest) transcription factor binding (Rest)
Anatomy Link Frequency
neuronal 2
internal 2
Rest (Mus musculus)
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 160 98.04 Very High Very High Very High
Central nervous system 2 41.20 Quite Low
Morphine 6 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 28 100.00 Very High Very High Very High
Disease 8 100.00 Very High Very High Very High
Neurodegenerative Disease 2 65.00 Quite High
Targeted Disruption 4 61.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is probable that the silencing of NRSF target genes in Huntinton's disease could also be the result of additive or synergic repression through increasing interaction with Sp3 or other transcriptional factors resulting from abnormal presence of NRSF in neuronal cells.
Positive_regulation (increasing) of NRSF Binding (interaction) of Sp3 in neuronal associated with repression and disease
1) Confidence 0.41 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.82 Pain Relevance 0.07
Because two short isoforms are generated by internal start codon, it can be speculated that the N-terminal region (112 amino acid residues) of Sp3, which is absent from the two short isoforms, takes responsibility for the interaction of the full-length Sp3 with NRSF and for determining the role of Sp3 factors for MOR gene expression.
Positive_regulation (responsibility) of NRSF Binding (interaction) of Sp3 in internal associated with mu opioid receptor
2) Confidence 0.41 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.06 Pain Relevance 0.17

General Comments

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