INT200323

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) nucleus (Sp3) intracellular (Sp3)
plasma membrane (Oprm1) DNA binding (Sp3) signal transducer activity (Oprm1)
Oprm1 (Mus musculus)
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 320 100.00 Very High Very High Very High
Morphine 12 5.00 Very Low Very Low Very Low
opioid receptor 12 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 56 50.00 Quite Low
Disease 16 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To validate the functional Sp3 binding to MOR promoter in vivo, we carried out the in vivo ChIP assay using several antibodies.
MOR promoter Binding (binding) of Sp3 associated with mu opioid receptor
1) Confidence 0.39 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.23
The results clearly demonstrated that Sp3 factor binds the G/C motif and interacts with NRSF in MOR promoter region, suggesting that transcription factor Sp3 is required for silencing MOR expression together with NRSF.
MOR promoter Binding (interacts) of Sp3 factor associated with mu opioid receptor
2) Confidence 0.30 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.16
During subsequent PCR only those MOR DNA sequences that are simultaneously bound to both NRSF and Sp3 proteins should be amplified.
MOR Binding (bound) of Sp3 associated with mu opioid receptor
3) Confidence 0.26 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.33
The results clearly demonstrate that NRSF and Sp3 factor bind to the short MOR promoter segment with close proximity in vivo.


MOR promoter Binding (bind) of Sp3 factor associated with mu opioid receptor
4) Confidence 0.25 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.27

General Comments

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