INT200335

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.07
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rest) DNA binding (Rest) protein complex (Rest)
cytoplasm (Rest) signal transducer activity (Oprm1) cytosol (Rest)
Anatomy Link Frequency
neuronal 1
neuron 1
Oprm1 (Mus musculus)
Rest (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 480 100.00 Very High Very High Very High
opioid receptor 18 77.56 Quite High
Morphine 18 62.80 Quite High
Analgesic 6 61.88 Quite High
Central nervous system 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 84 69.28 Quite High
Targeted Disruption 12 8.16 Low Low
Disease 24 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been well established that the Zn2+-finger-containing protein REST/NRSF binds the 21 bp NRSE DNA element found in many neuronal genes including MOR and then nucleates the formation of a multiprotein complex that represses gene transcription by deacetylating histones, methylating both DNA and histone H3, and dephosphorylation of RNA polymerase II (15,18,33).
MOR Binding (binds) of NRSF in neuronal associated with mu opioid receptor
1) Confidence 0.40 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.07 Pain Relevance 0.15
The results clearly demonstrated that Sp3 factor binds the G/C motif and interacts with NRSF in MOR promoter region, suggesting that transcription factor Sp3 is required for silencing MOR expression together with NRSF.
MOR promoter Binding (interacts) of NRSF associated with mu opioid receptor
2) Confidence 0.31 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.16
During subsequent PCR only those MOR DNA sequences that are simultaneously bound to both NRSF and Sp3 proteins should be amplified.
MOR Binding (bound) of NRSF associated with mu opioid receptor
3) Confidence 0.27 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.33
The results clearly demonstrate that NRSF and Sp3 factor bind to the short MOR promoter segment with close proximity in vivo.


MOR promoter Binding (bind) of NRSF associated with mu opioid receptor
4) Confidence 0.26 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.27
Taken altogether, the co-immunoprecipitation and EMSA studies demonstrate that NRSF and Sp3 factor interact with each other and physically bind to the repressive element of the MOR promoter, NRSE/GC box.


MOR promoter Binding (bind) of NRSF associated with mu opioid receptor
5) Confidence 0.26 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.18
We have also reported that MOR transcription is suppressed by the neuron-restrictive silencer element (NRSE) in the mouse MOR promoter through binding of neuron-restriction silence factor (NRSF) (11).
MOR promoter Binding (binding) of NRSF in neuron associated with mu opioid receptor
6) Confidence 0.26 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.61

General Comments

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