INT200348

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) nucleus (Sp3)
intracellular (Sp3) DNA binding (Sp3) signal transducer activity (Oprm1)
Sp3 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 160 100.00 Very High Very High Very High
opioid receptor 6 8.32 Low Low
Morphine 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 28 92.88 High High
Targeted Disruption 4 79.72 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results have showed that Sp3 specifically binds to this mouse GC box and interacts with NRSF to synergistically repress the MOR expression.


Sp3 Negative_regulation (repress) of Gene_expression (expression) of MOR associated with mu opioid receptor
1) Confidence 0.48 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.40 Pain Relevance 0.10
end of NRSE and demonstrated that Sp3 transcription factor represses the expression of MOR gene by binding to this element and by interacting with NRSF.
Sp3 Negative_regulation (represses) of Gene_expression (expression) of MOR associated with mu opioid receptor
2) Confidence 0.35 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.45

General Comments

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