INT200354

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rest, Sp3) DNA binding (Rest, Sp3) nucleus (Rest, Sp3)
protein complex (Rest) signal transducer activity (Oprm1) cytoplasm (Rest)
Rest (Mus musculus)
Sp3 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 80 100.00 Very High Very High Very High
opioid receptor 3 8.32 Low Low
Morphine 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 92.88 High High
Targeted Disruption 2 79.72 Quite High
Disease 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results have showed that Sp3 specifically binds to this mouse GC box and interacts with NRSF to synergistically repress the MOR expression.


NRSF Binding (interacts) of Sp3 Negative_regulation (repress) of Gene_expression (expression) of MOR associated with mu opioid receptor
1) Confidence 0.34 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.40 Pain Relevance 0.10

General Comments

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