INT200369

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.76
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rorb) cellular_component (Rorb)
Anatomy Link Frequency
neuronal 1
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 60 100.00 Very High Very High Very High
mu opioid receptor 160 98.70 Very High Very High Very High
cINOD 3 93.92 High High
Analgesic 6 91.08 High High
cytokine 27 88.72 High High
Neuropathic pain 20 80.96 Quite High
ischemia 13 75.00 Quite High
Pain 13 68.48 Quite High
Intractable pain 2 63.80 Quite High
Endocannabinoid 25 52.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 100.00 Very High Very High Very High
Myocardial Infarction 78 99.44 Very High Very High Very High
Apoptosis 82 97.52 Very High Very High Very High
Toxicity 7 90.56 High High
Diabetes Mellitus 55 87.32 High High
Adhesions 12 84.56 Quite High
Syndrome 2 81.36 Quite High
Neuropathic Pain 32 80.96 Quite High
Disease 15 77.92 Quite High
Repression 28 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specificity of the assay was controlled by demonstrating that the addition of an excess of wild-type consensus RE (20 pmol/well) prevented transcription factor binding onto the well whereas an excess of mutated consensus RE remained ineffective.


Negative_regulation (prevented) of transcription
1) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0
Furthermore, treatment with CORM-2 significantly inhibited the activity of the pro-inflammatory transcription factor NF-?
Negative_regulation (inhibited) of transcription factor associated with inflammation
2) Confidence 0.04 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2873601 Disease Relevance 0.76 Pain Relevance 0.29
The phosphorylation status of Akt-regulated FOXO3a transcription factor was decreased in sham- and MI GK rats and MI Wistar rats (Figure 5C).
Negative_regulation (decreased) of transcription factor associated with myocardial infarction
3) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.77 Pain Relevance 0
However, R-flurbiprofen reduces inflammation [5] via inhibition of the transcription factor NF-?
Negative_regulation (inhibition) of transcription factor associated with inflammation
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.02 Pain Relevance 0.83
A recent study reported that the transcription levels of the several NRSF target genes containing GC-rich regions were decreased with mithramycin A in a dose-dependent manner in both ?
Negative_regulation (decreased) of transcription
5) Confidence 0.00 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.08 Pain Relevance 0.35
It has been well established that the Zn2+-finger-containing protein REST/NRSF binds the 21 bp NRSE DNA element found in many neuronal genes including MOR and then nucleates the formation of a multiprotein complex that represses gene transcription by deacetylating histones, methylating both DNA and histone H3, and dephosphorylation of RNA polymerase II (15,18,33).
Negative_regulation (represses) of transcription in neuronal associated with mu opioid receptor
6) Confidence 0.00 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.13 Pain Relevance 0.15

General Comments

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