INT200384

Context Info Confidence 0.25 First Reported 2006 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 5.46 Pain Relevance 2.41

cytosol (ADC) mitochondrion (ADC) small molecule metabolic process (ADC) lyase activity (ADC) cellular nitrogen compound metabolic process (ADC)

Anatomy Link Frequency basal ganglia 2 gray matter 1 amygdala 1 white matter 1 ADC (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 58 99.68 amygdala 116 98.88 imagery 331 93.84 ischemia 56 83.24 cytokine 31 64.60 Inflammation 30 64.20 Central nervous system 58 61.76 medulla 5 54.92 cerebral cortex 5 53.44 Limbic system 8 32.48

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 336 99.36 Pressure And Volume Under Development 32 86.64 Cv Unclassified Under Development 39 83.24 Brain Injury 21 82.00 Stress 55 79.44 Cv General 4 Under Development 15 76.88 Hypertension 10 75.00 Middle Cerebral Artery Infarction 8 75.00 Disease 48 74.72 Injury 107 71.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, measuring the CSF neopterin has diagnostic value in ADC, though not to a degree to provide sufficiently certain diagnosis on its own.

Regulation (value) of ADC

1) Confidence 0.25 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.41 Pain Relevance 0.06

ADC values between controls, patients with SLE, and patients with NP-SLE were tested using analysis of variance with post-hoc Bonferroni correction.

Regulation (values) of ADC associated with systemic lupus erythematosus

2) Confidence 0.06 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1702559 Disease Relevance 0.90 Pain Relevance 0.41

In contrast, we did not find significant changes in ADC of the white matter, gray matter, or the hippocampus.

Neg (not) Regulation (changes) of ADC in white matter associated with hippocampus

3) Confidence 0.06 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.94 Pain Relevance 0.41

Table 2 shows ADC values of the hippocampus and the amygdala in control participants, anti-NMDAR–negative NP-SLE patients, and anti-NMDAR–positive NP-SLE patients.

Regulation (values) of ADC in amygdala associated with hippocampus, systemic lupus erythematosus and amygdala

4) Confidence 0.06 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.86 Pain Relevance 0.37

Mean ADC and FA values with standard deviations for the piglets as a group at both time points were recorded (approximately n = 8500 ADC pixel values in each cohort).

Regulation (values) of ADC

5) Confidence 0.04 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.06 Pain Relevance 0.05

The mean ADC values obtained in this study at baseline are comparable with previously reported values, with a baseline ADC value of 101±7×10?

Regulation (values) of ADC

6) Confidence 0.04 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.25 Pain Relevance 0.16

All piglets had significantly lower ADC values in the basal ganglia after 7 hours compared to the baseline ADC values (P<0.001).

Regulation (values) of ADC in basal ganglia

7) Confidence 0.04 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.30 Pain Relevance 0.08

The mean ADC values obtained in this study at baseline are comparable with previously reported values, with a baseline ADC value of 101±7×10?

Regulation (value) of ADC

8) Confidence 0.04 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.23 Pain Relevance 0.18

Mean ADC values in the basal ganglia for the piglets as a group at baseline and after 7 hours were 101.37±12.44×10?

Regulation (values) of ADC in basal ganglia

9) Confidence 0.04 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.29 Pain Relevance 0.08

In contrast, we did not find significant changes in ADC of the white matter, gray matter, or the hippocampus.

Neg (not) Regulation (changes) of ADC in gray matter associated with hippocampus

10) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.94 Pain Relevance 0.41

Cortical ADC values in the parecoxib group were markedly less increased on Day 8 (p < 0.01).

Regulation (values) of ADC

11) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1764728 Disease Relevance 0.21 Pain Relevance 0.14

The mean cortical ADC values were 113% in the parecoxib group compared with 147% in the saline group (p < 0.03), which suggests delayed "pseudonormalization" within the treated animals (see Discussion) [32,33].

Regulation (values) of ADC

12) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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