INT200385

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 16.56
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADC) mitochondrion (ADC) small molecule metabolic process (ADC)
lyase activity (ADC) cellular nitrogen compound metabolic process (ADC)
Anatomy Link Frequency
CSF 1
brain 1
intracellular space 1
astrocyte 1
amygdala 1
ADC (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 516 100.00 Very High Very High Very High
amygdala 87 99.68 Very High Very High Very High
ischemia 136 99.36 Very High Very High Very High
Inflammation 59 96.00 Very High Very High Very High
Hippocampus 75 95.52 Very High Very High Very High
cytokine 64 94.96 High High
COX-2 inhibitor 35 78.52 Quite High
Central nervous system 67 73.20 Quite High
cva 33 30.60 Quite Low
aspirin 5 14.08 Low Low
Disease Link Frequency Relevance Heat
Viral Meningitis 17 99.96 Very High Very High Very High
Ketoacidosis 363 99.76 Very High Very High Very High
Systemic Lupus Erythematosus 252 99.64 Very High Very High Very High
Necrosis 60 99.56 Very High Very High Very High
Cv Unclassified Under Development 99 99.36 Very High Very High Very High
Pressure And Volume Under Development 240 99.08 Very High Very High Very High
Brain Hemorrhage 99 98.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 95 97.92 Very High Very High Very High
Stroke 77 97.24 Very High Very High Very High
INFLAMMATION 65 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel attention to CSF immunological biomarkers, including neopterin, declined after it was shown that HIV RNA levels could be measured in the CSF of most untreated patients and that high levels could often be detected in ADC/HIVE [6,9,10].
Negative_regulation (detected) of ADC in CSF associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
1) Confidence 0.18 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.09 Pain Relevance 0.04
In addition, the ADC in anti-NMDAR–positive patients is decreased (p = 0.029) compared to patients without these antibodies.


Negative_regulation (decreased) of ADC
2) Confidence 0.10 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.90 Pain Relevance 0.39
In patients with anti-NMDAR antibodies, the ADC was decreased (p = 0.001) compared to the healthy controls, whereas this was not the case (p = 0.262) for the patients without the anti-NMDAR antibodies.
Negative_regulation (decreased) of ADC
3) Confidence 0.10 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.83 Pain Relevance 0.39
In patients with SLE (p = 0.019) as well as in patients with NP-SLE (p = 0.006), the ADC was decreased in the amygdala compared to controls.
Negative_regulation (decreased) of ADC in amygdala associated with systemic lupus erythematosus and amygdala
4) Confidence 0.10 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.79 Pain Relevance 0.38
In the current study, the persistent reduction in ADC 7 hours after HI is consistent with the histological confirmation of irreversible cell damage.
Negative_regulation (reduction) of ADC
5) Confidence 0.08 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.25 Pain Relevance 0.17
Reduced ADC and the presence of lactate were strongly correlated to tissue damage.
Negative_regulation (Reduced) of ADC
6) Confidence 0.06 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.70 Pain Relevance 0.14
Presence of necrosis correlated well with reduced ADC (RS = 0.91) and presence of Lac (RS = 0.80).
Negative_regulation (reduced) of ADC associated with necrosis
7) Confidence 0.06 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Abstract Doc Link PMC2582156 Disease Relevance 0.59 Pain Relevance 0.29
This would explain elevated FA, reduced ADC, and normal T2 (33).
Negative_regulation (reduced) of ADC
8) Confidence 0.06 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.24 Pain Relevance 0.04
A previous study has shown that ADC reduction during HI in a piglet model is reversible after 30 min (9).
Negative_regulation (reduction) of ADC
9) Confidence 0.06 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.70 Pain Relevance 0.26
In a recent study in five neonates with severe HI, ADC was shown to be significantly reduced in the cerebrum relative to the unaffected cerebellum (30).
Negative_regulation (reduced) of ADC in cerebellum
10) Confidence 0.06 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.31 Pain Relevance 0.17
Many studies have shown that the apparent diffusion coefficient (ADC), as measured by DWI, is reduced in the hyperacute phase following an HI event due to influx of water from the extra- to the intracellular space (8).
Negative_regulation (reduced) of ADC in intracellular space associated with imagery
11) Confidence 0.06 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.71 Pain Relevance 0.25
We found indications of a significant correlation between the ADC decrease and the IL-1?
Negative_regulation (decrease) of ADC
12) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.69 Pain Relevance 0.14
Others have also demonstrated less ADC reduction in early focal ischemia after neuroprotective therapy in experimental animal studies [48].
Negative_regulation (reduction) of ADC associated with ischemia
13) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.82 Pain Relevance 0.25
IP parecoxib administration (10 mg/kg) during tMCAo was neuroprotective as evidenced by a large reduction in mean infarct volume and cortical ADC measurements one week after tMCAo.
Negative_regulation (reduction) of ADC
14) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.56 Pain Relevance 0.20
As proposed by Mancuso et al. [52], we believe that the initial ADC decrease can be linked to the degree of neuroinflammation following tMCAo.
Negative_regulation (decrease) of ADC
15) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.66 Pain Relevance 0.14
We observed a beneficial effect of parecoxib administration based on ADC measurements, as hyperacute ADC reduction was less pronounced in parecoxib-treated than in saline-treated animals.
Negative_regulation (reduction) of ADC
16) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.68 Pain Relevance 0.26
ADC values were reduced, consistent with cell swelling.
Negative_regulation (reduced) of ADC associated with pressure and volume under development
17) Confidence 0.02 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551666 Disease Relevance 1.42 Pain Relevance 0.09
Rats with DKA manifest a reduction of apparent diffusion coefficient (ADC) values for brain water, indicating cytotoxic edema, and administration of the Na-K-Cl cotransport inhibitor bumetanide, which has been shown to reduce both astrocyte and brain microvascular endothelial cell swelling under hypoxic and ischemic conditions (13–17), returns ADC values to normal (18).
Negative_regulation (reduction) of ADC in brain associated with pressure and volume under development, hypoxia and ketoacidosis
18) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 2.32 Pain Relevance 0
Rats with DKA manifest a reduction of apparent diffusion coefficient (ADC) values for brain water, indicating cytotoxic edema, and administration of the Na-K-Cl cotransport inhibitor bumetanide, which has been shown to reduce both astrocyte and brain microvascular endothelial cell swelling under hypoxic and ischemic conditions (13–17), returns ADC values to normal (18).
Negative_regulation (reduction) of ADC in astrocyte associated with pressure and volume under development, hypoxia and ketoacidosis
19) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 2.32 Pain Relevance 0

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