INT200401

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.42
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNE1) lysosome (KCNE1)
KCNE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 12 96.40 Very High Very High Very High
Action potential 14 95.88 Very High Very High Very High
beta blocker 9 53.80 Quite High
sodium channel 26 5.00 Very Low Very Low Very Low
Pain 21 5.00 Very Low Very Low Very Low
Calcium channel 10 5.00 Very Low Very Low Very Low
Mexiletine 6 5.00 Very Low Very Low Very Low
Catecholamine 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 106 99.92 Very High Very High Very High
Injury 543 98.96 Very High Very High Very High
Cancer 360 92.16 High High
Syndrome 240 90.12 High High
Disease 67 89.56 High High
Liver Cancer 130 89.20 High High
Reprotox - General 1 40 88.72 High High
Channelopathies 7 88.16 High High
Renal Cancer 30 79.28 Quite High
Andersen Syndrome 18 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KCNQ1 gene and the KCNE1 gene encode respectively the alpha (KvLQT1) and the ?
Gene_expression (gene) of KCNE1
1) Confidence 0.57 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.09 Pain Relevance 0.10
LQT1, LQT5, JLN1, JLN2: KCNQ1 (causing LQT1 and JLN1) and KCNE1 (causing LQT5 and JLN2) encode respectively for the alpha (KvLQT1) and the beta (MinK) subunits of the potassium channel conducting the IKs current, the slow component of the delayed rectifier current (IK) the major repolarizing current during phase 3 of the cardiac action potential.
Gene_expression (causing) of KCNE1 associated with action potential and potassium channel
2) Confidence 0.20 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.61 Pain Relevance 0.12
LQT1, LQT5, JLN1, JLN2: KCNQ1 (causing LQT1 and JLN1) and KCNE1 (causing LQT5 and JLN2) encode respectively for the alpha (KvLQT1) and the beta (MinK) subunits of the potassium channel conducting the IKs current, the slow component of the delayed rectifier current (IK) the major repolarizing current during phase 3 of the cardiac action potential.
Gene_expression (causing) of KCNE1 associated with action potential and potassium channel
3) Confidence 0.20 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.61 Pain Relevance 0.12
LQT1, LQT5, JLN1, JLN2: KCNQ1 (causing LQT1 and JLN1) and KCNE1 (causing LQT5 and JLN2) encode respectively for the alpha (KvLQT1) and the beta (MinK) subunits of the potassium channel conducting the IKs current, the slow component of the delayed rectifier current (IK) the major repolarizing current during phase 3 of the cardiac action potential.
Gene_expression (causing) of LQT5 associated with action potential and potassium channel
4) Confidence 0.20 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.61 Pain Relevance 0.12
Table 1 shows the combinations of proportionality (kp) and derivative (kd) constants used in the feedback loop to achieve different HRs (100, 200, 300 and 525°C min?
Gene_expression (achieve) of min
5) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0 Pain Relevance 0
It was also observed that for a given target PT (>70°C)–HR (<50°C min?
Gene_expression (<50) of min
6) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.49 Pain Relevance 0
A smaller flat portion representing complete cell death and the steeper vertical portion representing considerable (>10%) survival for zero hold time in Fig. 5a intersects at 70°C and complete cell death is observed for HRs of 50°C min?
Gene_expression (observed) of min associated with death
7) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.81 Pain Relevance 0
0.001%) was predicted for target PTs of 60–85°C and HRs of 5–600°C min?
Gene_expression (predicted) of min
8) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.42 Pain Relevance 0
The data in Fig. 4a–c represents the mean and the standard error of the measured cell viability using Ethd-1 dye uptake assay for attached HepG2 cells at HRs of 100, 200 and 300°C min?
Gene_expression (assay) of min
9) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.27 Pain Relevance 0
1 were obtained for HRs of 5–600°C min?
Gene_expression (obtained) of min
10) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.45 Pain Relevance 0
This is due to the fact that for HRs above 50°C min?
Gene_expression (above) of min
11) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.37 Pain Relevance 0
This is due to the fact that for HRs above 50°C min?
Gene_expression (for) of min
12) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.37 Pain Relevance 0
The HRs of 100, 200 and 300°C min?
Gene_expression (The) of min
13) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0.33 Pain Relevance 0
The above equation was then used to obtain the values of activation energy over a range of HRs from 5 to 600°C min?
Gene_expression (obtain) of min
14) Confidence 0.09 Published 2006 Journal Ann Biomed Eng Section Body Doc Link PMC1705482 Disease Relevance 0 Pain Relevance 0

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