INT200421

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.72
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
plasma 1
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 13 100.00 Very High Very High Very High
ischemia 88 99.36 Very High Very High Very High
ketamine 3 55.24 Quite High
Potency 4 53.84 Quite High
Kinase C inhibitor 1 22.96 Low Low
Kinase C 2 17.20 Low Low
anesthesia 6 10.08 Low Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Raphe 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 78 99.36 Very High Very High Very High
Reperfusion Injury 3 77.28 Quite High
Death 11 51.96 Quite High
Drug Induced Neurotoxicity 20 50.00 Quite Low
Ocular Hypertension 5 34.96 Quite Low
Sprains And Strains 4 28.92 Quite Low
Retina Disease 9 22.24 Low Low
Reprotox - General 1 1 20.56 Low Low
Aging 3 16.52 Low Low
Body Weight 2 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of perchloric acid was necessary to precipitate proteins and release the MDA bound to the amino groups of proteins and other amino compounds.
Localization (release) of MDA
1) Confidence 0.22 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0 Pain Relevance 0
Interestingly, in the present study in which the duration of ischemia was doubled (180 min) compared to the study of Ceylan et al [10], both single and triple applications of 10 min (group 2, group 5) ischemic preconditioning significantly reduced MDA increase in response to ischemia in rat testicular tissue.
Localization (increase) of MDA associated with ischemia
2) Confidence 0.13 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2231361 Disease Relevance 0.72 Pain Relevance 0.29
Malondialdehyde (MDA) measurement
Localization (measurement) of MDA
3) Confidence 0.11 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2913934 Disease Relevance 0 Pain Relevance 0
Reagent kits of alkaline phosphatase (AKP), acid phosphatase (ACP), lactate dehydrogenase (LDH), superoxide dismutase (SOD), reduced glutathione hormone (GSH), malondialdehyde (MDA), sorbitol dehydrogenase (SDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide (NO) and nitric oxide synthase (NOS) were purchased from Nanjing Jiancheng Bioengineering Institute (CHINA).


Localization (aminotransferase) of MDA
4) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
Like other substrate-type releasers, MDMA and MDA bind to plasma membrane monoamine transporters and are translocated into the cytoplasm.
Localization (translocated) of MDA in plasma associated with monoamine
5) Confidence 0.08 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0 Pain Relevance 0.19

General Comments

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