INT200429

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) small molecule metabolic process (TPH1) cellular nitrogen compound metabolic process (TPH1)
response to stress (TPH1)
TPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 9 72.96 Quite High
monoamine 13 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Raphe 7 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 5 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Nucleus accumbens 3 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 20 93.60 High High
Urological Neuroanatomy 10 71.36 Quite High
Fever 11 5.00 Very Low Very Low Very Low
Anxiety Disorder 10 5.00 Very Low Very Low Very Low
Nash(non-alcoholic Steatohepatitis) 6 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Gliosis 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As noted previously, high-dose MDMA causes persistent inactivation of tryptophan hydroxylase, which leads to inhibition of 5-HT synthesis and loss of 5-HT (O’Hearn et al. 1988; Stone et al. 1987).
Positive_regulation (causes) of Negative_regulation (inactivation) of tryptophan hydroxylase
1) Confidence 0.01 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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