INT200435

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.56
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 65 86.24 High High
Central nervous system 11 83.00 Quite High
headache 2 82.84 Quite High
Pain 5 75.08 Quite High
Neuritis 1 65.84 Quite High
Bioavailability 8 60.00 Quite High
Neuronal excitability 2 43.96 Quite Low
Inflammation 16 30.64 Quite Low
peripheral neuropathy 1 25.64 Quite Low
Neurotransmitter 1 24.48 Low Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 5 99.98 Very High Very High Very High
Herpes Simplex Virus 3 99.84 Very High Very High Very High
Herpes Zoster 1 99.20 Very High Very High Very High
Cytomegalovirus Infection 123 98.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 36 97.64 Very High Very High Very High
Infection 121 95.24 Very High Very High Very High
Dengue 126 94.64 High High
Blindness 6 94.28 High High
Retinitis 81 93.12 High High
Herpes Simplex Virus Infection 23 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the antivirals are further phosphorylated by cellular enzymes, they compete with nucleosides to bind to the viral DNA polymerase, resulting in polymerase inactivation and a decrease in viral replication [16].
polymerase Binding (bind) of
1) Confidence 0.16 Published 2006 Journal Arch Gynecol Obstet Section Body Doc Link PMC1705528 Disease Relevance 0.73 Pain Relevance 0.20
Both POLG1 mutations, p.R722H and p.W748S, are situated in the linker region which mediates interaction between the polymerase and exonuclease domains, so that mutations might lead to a significant reduction in the enzyme activity in vitro [31].
polymerase Spec (might) Binding (interaction) of
2) Confidence 0.05 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.94 Pain Relevance 0.08
The G2 RNP complex also had a significantly higher polymerase activity at 33°C (+30%) but a slightly lower one at 39°C (?
polymerase Binding (activity) of
3) Confidence 0.03 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.19 Pain Relevance 0
terminal contains blocking groups, the DNA polymerase can add between 2 and 8 nt, with consequent strand displacement, flap processing and finally ligation.
polymerase Binding (ligation) of
4) Confidence 0.02 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.48 Pain Relevance 0.11
We previously showed that these mutations had no impact on X binding efficiency to P or its ability to interfere with the polymerase activity [29].
polymerase Binding (interfere) of
5) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.52 Pain Relevance 0.08
HCV polymerase has also been shown to interact with a ubiquitin-like protein leading to its degradation [43].
polymerase Binding (interact) of associated with hepatitis c virus infection
6) Confidence 0.01 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.69 Pain Relevance 0
It interferes with the binding of the diphosphate to the viral DNA polymerase of Herpes simplex, Varicella zoster, cytomegalovirus, and HIV.28
polymerase Binding (binding) of associated with herpes simplex virus, acquired immune deficiency syndrome or hiv infection, herpes zoster and cytomegalovirus infection
7) Confidence 0.01 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861935 Disease Relevance 1.00 Pain Relevance 0

General Comments

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