INT20044

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 50
Total Number 52
Disease Relevance 29.96
Pain Relevance 26.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
NK cell 16
Poly 2
T cells 2
macrophages 1
GPI 1
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 157 99.98 Very High Very High Very High
fortral 18 99.98 Very High Very High Very High
Enkephalin 4 99.86 Very High Very High Very High
substance P 6 99.76 Very High Very High Very High
ketamine 6 99.70 Very High Very High Very High
tolerance 10 99.62 Very High Very High Very High
Analgesic 28 99.52 Very High Very High Very High
Angina 8 99.52 Very High Very High Very High
Opioid 82 99.46 Very High Very High Very High
anesthesia 59 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 428 99.96 Very High Very High Very High
Hemophagocytic Lymphohistiocytosis 286 99.96 Very High Very High Very High
Disease 217 99.90 Very High Very High Very High
Macrophage Activation Syndrome 377 99.84 Very High Very High Very High
Cv General 3 Under Development 10 99.52 Very High Very High Very High
INFLAMMATION 138 99.36 Very High Very High Very High
Stress 28 99.36 Very High Very High Very High
Congenital Anomalies 80 99.32 Very High Very High Very High
Hemolysis 59 99.30 Very High Very High Very High
Infection 404 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral lymphocytes from cancer patients following major surgery also showed depressed NK activity.
Negative_regulation (depressed) of NK in lymphocytes associated with cancer
1) Confidence 0.59 Published 1983 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 6674793 Disease Relevance 0.19 Pain Relevance 0.08
In vitro exposure to corticosterone is known to suppress NK activity directly, whereas in vitro morphine was unable to alter directly NK activity.
Negative_regulation (suppress) of NK associated with morphine
2) Confidence 0.50 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.32
A dose of 10.0 mg/kg of morphine produced 35% of the maximal possible effect in the analgesia study and no immunosuppression, whereas a dose of 32.0 mg/kg produced a maximal analgesic effect and significant suppression of NK activity.
Negative_regulation (suppression) of NK associated with analgesic, analgesia and morphine
3) Confidence 0.43 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182537 Disease Relevance 0 Pain Relevance 1.80
The glucocorticoid receptor antagonist Roussel-Uclaf 38486 blocked morphine-induced suppression of NK activity in a dose-responsive fashion.
Negative_regulation (suppression) of NK associated with antagonist and morphine
4) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.22
The opiate antagonists naloxone and naltrexone completely blocked morphine-induced suppression of NK activity, whereas naloxone methiodide, a congener that crosses the blood-brain barrier much more slowly than naloxone, produced very little blockade.
Negative_regulation (suppression) of NK in brain associated with antagonist, narcan, opiate and morphine
5) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.40
In addition, morphine-induced suppression of splenic NK activity was antagonized in a dose-dependent manner and, at one dose of naltrexone (10.0 mg/kg), splenic NK activity was augmented.
Negative_regulation (suppression) of NK associated with morphine
6) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182537 Disease Relevance 0 Pain Relevance 1.26
NK activity in the B6C3F1 mouse was suppressed between 12 and 48 hr after implantation of 75 mg timed-release morphine pellets.
Negative_regulation (suppressed) of NK associated with morphine
7) Confidence 0.37 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.21
Morphine suppressed NK activity in a dose-responsive manner.
Negative_regulation (suppressed) of NK associated with morphine
8) Confidence 0.37 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.32
In contrast to anesthesia alone, anesthesia with surgery significantly decreased baseline NK activity.
Negative_regulation (decreased) of NK associated with anesthesia
9) Confidence 0.36 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 1.06
It is an essential glycolytic enzyme, expressed by all cells, and G6PI deficiency is lethal at the two-cell stage [68].
Negative_regulation (deficiency) of G6PI
10) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.93 Pain Relevance 0.31
G6PI deposits, together with IgG and C3, are detectable in the joints of arthritic mice in the K/B×N serum transfer model [98].
Negative_regulation (deposits) of G6PI in joints associated with arthritis
11) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.73 Pain Relevance 0.21
SP, Enk, VIP, PHI, and BLIP levels were all decreased in the distal colon of piebald mice as compared to normal littermates, SP, BLIP, and Enk levels were also decreased in the dilated proximal colon of piebald mice.
Negative_regulation (decreased) of PHI in proximal associated with enkephalin and substance p
12) Confidence 0.28 Published 1985 Journal J. Surg. Res. Section Abstract Doc Link 3990276 Disease Relevance 0.24 Pain Relevance 0.70
Since this effect was reproduced using three different anesthetics (Avertin, ether, and Ketamine/Xylazan), the inhibition of inducible NK activity is probably due to the state of general anesthesia, rather than to the pharmacological properties of the anesthetics.
Negative_regulation (inhibition) of NK associated with anesthesia and ketamine
13) Confidence 0.27 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 0.83
Interestingly, neither anesthesia alone nor anesthesia with surgery were able to significantly decrease splenic NK activity that had been induced with Poly I:C prior to anesthesia.
Negative_regulation (decrease) of NK in Poly associated with anesthesia
14) Confidence 0.27 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 1.03
However, the addition of surgery to anesthesia did not significantly alter the level of inhibition of NK stimulation by Poly I:C compared to anesthesia treatment alone.
Negative_regulation (inhibition) of NK in Poly associated with anesthesia
15) Confidence 0.27 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 1.07
HPA activation alters levels of glucocorticoids (GC) and opioids which are associated with suppression of lymphoid cellularity and NK activity.
Negative_regulation (suppression) of NK associated with opioid
16) Confidence 0.26 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 1.03 Pain Relevance 0.38
RST of infected mice significantly suppressed splenic CD3(-)DX5+ cellularity and NK cytolytic activity.
Negative_regulation (suppressed) of NK associated with stress
17) Confidence 0.23 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 1.13 Pain Relevance 0.51
Nonetheless, parenteral administration of the sigma receptor ligand BD 1165 blocked (+)-pentazocine-induced suppression of NK activity, while the opiate receptor antagonist naltrexone was ineffective.
Negative_regulation (suppression) of NK associated with fortral, antagonist, opiate and parenteral administration
18) Confidence 0.20 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862129 Disease Relevance 0 Pain Relevance 0.78
The failure of diazepam to suppress NK activity also suggests that increased chloride flux through diazepam-sensitive GABA-A receptors (which is caused by EtOH as well as diazepam) does not mediate NK suppression in this model.
Negative_regulation (suppress) of NK associated with gaba
19) Confidence 0.19 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.58
For example, at a dose of 50 mg/kg, (+)-pentazocine suppressed NK activity (using effector to target cell ratios of 200:1, 100:1 and 50:1) by > 70%, 24 h after injection while (-)-pentazocine was inactive.
Negative_regulation (suppressed) of NK associated with fortral
20) Confidence 0.18 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862129 Disease Relevance 0 Pain Relevance 0.76

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