INT200442

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.12
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (AES)
AES (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 15 95.84 Very High Very High Very High
rheumatoid arthritis 30 90.16 High High
Infliximab 38 88.16 High High
sSRI 28 70.16 Quite High
psoriasis 27 46.48 Quite Low
Etanercept 3 38.48 Quite Low
Adalimumab 1 37.28 Quite Low
methotrexate 22 5.00 Very Low Very Low Very Low
corticosteroid 13 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthropathy 97 99.98 Very High Very High Very High
Diarrhoea 11 99.76 Very High Very High Very High
Infection 56 99.68 Very High Very High Very High
Weight Gain 12 99.60 Very High Very High Very High
Vomiting 11 98.12 Very High Very High Very High
Headache 15 95.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 19 95.44 Very High Very High Very High
Anxiety Disorder 14 95.04 Very High Very High Very High
Sleep Disorders 17 94.08 High High
Schizophrenia 48 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arthropathy AEs appeared to be less likely to occur in patients who had a good clinical response to treatment (?
Spec (likely) Positive_regulation (occur) of Spec (likely) Gene_expression (likely) of AEs associated with arthropathy
1) Confidence 0.42 Published 2006 Journal Arch Dermatol Res Section Body Doc Link PMC1705535 Disease Relevance 1.26 Pain Relevance 0
Discontinuation because of AEs occurred more often with dapoxetine 60 mg than with dapoxetine 30 mg.61,63,64,69
Positive_regulation (because) of Gene_expression (occurred) of AEs
2) Confidence 0.34 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695237 Disease Relevance 0.68 Pain Relevance 0.11
Otherwise, we did not identify significant risk factors for AEs overall, SAEs, infections, or IRs in this study.
Positive_regulation (overall) of Gene_expression (overall) of AEs associated with infection
3) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911915 Disease Relevance 0.83 Pain Relevance 0.21
The most commonly observed AEs occurring in ?
Positive_regulation (observed) of Gene_expression (observed) of AEs
4) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656329 Disease Relevance 0.81 Pain Relevance 0.16
While higher doses may produce further benefit, this strategy is mitigated by a dose-related increase in some AEs, such as QTc prolongation, EPS and weight gain.
Positive_regulation (increase) of Gene_expression (prolongation) of AEs associated with weight gain
5) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656329 Disease Relevance 0.87 Pain Relevance 0
The severe AEs
Positive_regulation (severe) of Gene_expression (severe) of AEs
6) Confidence 0.17 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.68 Pain Relevance 0

General Comments

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