INT200455

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CCL2) cytoplasm (CCL2) signal transducer activity (OPRK1)
extracellular space (CCL2) signal transduction (CCL2) extracellular region (CCL2)
Anatomy Link Frequency
neuronal 2
OPRK1 (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 6 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
Morphine 50 99.32 Very High Very High Very High
antagonist 3 91.24 High High
opioid receptor 15 90.40 High High
chemokine 14 67.52 Quite High
opiate 7 29.76 Quite Low
Inflammation 5 26.88 Quite Low
Central nervous system 6 24.48 Low Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 73.76 Quite High
INFLAMMATION 5 26.88 Quite Low
Apoptosis 2 6.96 Low Low
Dementia 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Experimental Autoimmune Encephalomyelitis 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observation that the KOR selective agonist U50, 488 did not enhance neuronal CCL2 production, suggested that morphine's effect is not acting through KORs.
KOR Neg (not) Positive_regulation (enhance) of Gene_expression (production) of CCL2 in neuronal associated with agonist, kappa opioid receptor and morphine
1) Confidence 0.19 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.07 Pain Relevance 1.21

General Comments

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