INT2005
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Most of the above mentioned medications lead to an increase in prolactin plasma concentration through an influence on prolactin secretion control, primarily removing inhibitor pathways or directly stimulating prolactin production by the lactotroph cells. | |||||||||||||||
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However, Schlienger et al showed that basal plasma levels of prolactin and delta prolactin response to TRH were increased in women on clomipramine but remained normal under maprotiline, in agreement with the different pharmacologic effect of these two classes of drugs, tricyclics mainly inhibiting serotonin, while tetracyclics rather norepinephrine recaptation (Schlienger et al 1980). | |||||||||||||||
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Histamine-induced prolactin production is mediated by dopaminergic as well as serotoninergic neurons, but other PRFs (eg, beta-endorphin, VIP, vasopressin or TRH) may be involved (Knigge 1990). | |||||||||||||||
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Histamine-induced prolactin production is mediated by dopaminergic as well as serotoninergic neurons, but other PRFs (eg, beta-endorphin, VIP, vasopressin or TRH) may be involved (Knigge 1990). | |||||||||||||||
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Eldib et al in their unpublished study on 20 women with PCOS showed that LOD was associated with increased PRL levels by 7 folds two weeks after operation. | |||||||||||||||
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Single nucleotide polymorphisms across the PRL extrapituitary promoter region have been associated with a relative overexpression of the PRL gene in SLE [14]. | |||||||||||||||
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1 may increase expression of PRL in endometrial stromal cells (ESC) [21], [22]. | |||||||||||||||
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Five patients had increased L PRL levels, but excess G PRL. | |||||||||||||||
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In response to TRH (200 micrograms, iv), PRL levels increased by 493 +/- 86% (mean +/- SE) over basal levels. | |||||||||||||||
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However, Schlienger et al showed that basal plasma levels of prolactin and delta prolactin response to TRH were increased in women on clomipramine but remained normal under maprotiline, in agreement with the different pharmacologic effect of these two classes of drugs, tricyclics mainly inhibiting serotonin, while tetracyclics rather norepinephrine recaptation (Schlienger et al 1980). | |||||||||||||||
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The net effect is an elevation of prolactin levels through increase in amplitude of prolactin bursts, release and storage (Halbreich et al 2003). | |||||||||||||||
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Treatment with either clomipramine or maprotiline in 17 patients with major depressive disorder and in healthy subjects increased significantly basal prolactin levels, that were also significantly higher in responders than in non-responders. | |||||||||||||||
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A long list of other compounds may determine an increase in prolactin levels, including prokinetics, opiates, estrogens, anti-androgens, anti-hypertensive drugs, H2-receptor antagonists, anti-convulsivants and cholinomimetics. | |||||||||||||||
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These results suggest that in contrast to risperidone, where baseline prolactin levels were elevated 5.3-fold in female and 4.2-fold in male patients, baseline prolactin levels were not elevated after treatment with perospirone (Togo et al 2003). | |||||||||||||||
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The robust increase in prolactin levels found in response to the GABA agonist alprazolam is not consistent with previous data on traditional benzodiazepines: Zemishlany et al reported that plasma prolactin levels increased by 100% two to eight hours after a single dose (3 mg) of alprazolam (Zemishlany et al 1990). | |||||||||||||||
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-receptor binding, indirect simulation of prolactin synthesis through VIP and OT gene expression enhancement. | |||||||||||||||
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This study establishes that (1) frequent uterine luminal fluid sampling is possible; (2) uterine luminal fluid volume decreases in the luteal phase; (3) uterine luminal fluid prolactin is detectable in vivo in women and its concentration increases in the luteal phase; and (4) cyclic human uterine luminal fluid prolactin levels differ from those in cynomolgus monkeys and from those anticipated from human in vitro studies. | |||||||||||||||
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An elevated PRL level was common finding during and after operation with the peak PRL levels always occurring during surgery. | |||||||||||||||
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When the DA antagonist metoclopramide was given in vivo to SLE patients, increased pituitary PRL responsiveness was demonstrated. | |||||||||||||||
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This means that prolactin levels increase or decrease one month before a corresponding change in the number of active lesions is observed on MRI. | |||||||||||||||
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