INT20050

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Context Info
Confidence 0.73
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.09
Pain Relevance 0.34

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small molecule metabolic process (UGT1A4) endoplasmic reticulum (UGT1A4) enzyme binding (UGT1A4)
Anatomy Link Frequency
hepatocytes 1
liver 1
UGT1A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 92.52 High High
Opioid 2 64.16 Quite High
Buprenorphine 1 62.00 Quite High
Inflammation 3 45.44 Quite Low
agonist 13 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 93.36 High High
INFLAMMATION 3 45.44 Quite Low
Van Bogaert's Disease 7 14.16 Low Low
Toxicity 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Gallstones 2 5.00 Very Low Very Low Very Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 1 5.00 Very Low Very Low Very Low
Wound Healing 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to expressed human UGT1A4, which catalyzes the glucuronidation of amines with high efficiency, glucuronidation of amines catalyzed by UGT1A3 exhibited low efficiency, suggesting that UGT1A3 makes only a limited contribution to the metabolic elimination of these compounds.
Gene_expression (expressed) of UGT1A4
1) Confidence 0.73 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9616184 Disease Relevance 0 Pain Relevance 0.19
Glucuronidation of 1'-HE was not detected in cells expressing UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, and UGT1A10. 1'-HE glucuronidation in 27 individual human liver samples significantly (p < 0.05) correlated with the glucuronidation of other UGT2B7 substrates (morphine and ibuprofen).
Gene_expression (expressing) of UGT1A4 in liver associated with morphine
2) Confidence 0.57 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12657745 Disease Relevance 0 Pain Relevance 0.09
In a recent study by Senekeo-Effenberger et al. [125], Wy-14,643 treatment of primary cultured human hepatocytes increased the levels of UGT1A1, UGT1A3, UGT1A4, and UGT1A6, but not UGT1A9, mRNAs.
Gene_expression (levels) of UGT1A4 in hepatocytes
3) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.09 Pain Relevance 0
The deduced amino acid sequence of estriol UDPGT showed 82% identity with the deduced amino acid sequence of another human hepatic cDNA (HLUG25), which has been expressed as a UDPGT capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid, strongly suggesting that these proteins are members of the same gene subfamily.
Gene_expression (expressed) of UDPGT
4) Confidence 0.26 Published 1990 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2116769 Disease Relevance 0 Pain Relevance 0.06

General Comments

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