INT200550

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.22
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
epithelial cell 2
platelet 1
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 1 98.84 Very High Very High Very High
Arthritis 8 98.56 Very High Very High Very High
antagonist 11 79.80 Quite High
Inflammation 59 75.64 Quite High
aspirin 30 55.28 Quite High
rheumatoid arthritis 57 45.68 Quite Low
imagery 24 5.00 Very Low Very Low Very Low
ischemia 24 5.00 Very Low Very Low Very Low
substance P 22 5.00 Very Low Very Low Very Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 69 99.60 Very High Very High Very High
Pre-eclampsia 408 99.32 Very High Very High Very High
Cancer 106 98.80 Very High Very High Very High
Arthritis 8 98.56 Very High Very High Very High
Hypertension 98 98.28 Very High Very High Very High
Diabetes Mellitus 73 97.40 Very High Very High Very High
Shock 5 92.62 High High
Hyperoxia 21 90.20 High High
Adhesions 2 86.88 High High
Adult Respiratory Distress Syndrome 153 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sequential change in sFlt1, sEng and the ratio of these angiogenic factors in early pregnancy is associated with a significant increase in the odds of developing preeclampsia.
Regulation (change) of sFlt1 associated with pre-eclampsia
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 1.00 Pain Relevance 0.03
To verify if epithelial cell death was related to the down-regulation of VEGF and VEGFR-1, TUNEL and cytokeratin double staining was performed.
Regulation (regulation) of VEGFR-1 in epithelial cell associated with death
2) Confidence 0.32 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.33 Pain Relevance 0
Investigations on the effect of anti-Flt-1 peptide GNQWFI on an experimental model of arthritis are under way.

5.

Regulation (effect) of anti-Flt-1 peptide associated with arthritis
3) Confidence 0.25 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.49 Pain Relevance 0.13
The significant negative correlation between VEGFR-1 positive cells and epithelial cell death suggests that down-regulation of VEGFR-1 may be due to epithelial cell death.
Regulation (regulation) of VEGFR-1 in epithelial cell associated with death
4) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.48 Pain Relevance 0
Sunitinib and sorafenib are multitargeting TKIs that can block activity angiogenic targets such as of VEGFR1, 2, 3, platelet-derived growth factor (PDGF) receptors and c-Kit or RET.
Regulation (targets) of VEGFR1 in platelet
5) Confidence 0.23 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.37 Pain Relevance 0
These data are similar to that previously reported among low-risk patients, such that women who developed preeclampsia were more likely to show greater sequential changes in sFlt1 and sEng in early pregnancy, and these changes were most pronounced in preterm preeclampsia [13].
Regulation (changes) of sFlt1 associated with pre-eclampsia
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.73 Pain Relevance 0
We also observed that the change in sFlt1 and sEng, and the change in the ratio of the angiogenic factors between study entry (7–26 weeks' gestation) and the second study visit (24–28 weeks' gestation) was associated with a significant increase in the odds of developing preeclampsia among these high-risk populations.
Regulation (change) of sFlt1 associated with pre-eclampsia
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.82 Pain Relevance 0
The non-specific duplex RNA had no effects on cell viability and protein levels of VEGF and VEGFR-1 in comparison with non-treated control.


Neg (no) Regulation (effects) of VEGFR-1
8) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.27 Pain Relevance 0
Overall NK1R-dependent genes were classified following the biological processes with which they are involved (GO anthology): apoptosis (GZMA, TNFRSF1B, TNFRSF1A, TRAF3, NOS2A, and BID); cell adhesion/hyaluronic acid binding (CD44 and AGC1); cell cycle (CCND2 and CCNG1); cell-cell signaling (FGF11 and GJA7); cytokinesis (CDC42 and KIF1B); development (FMR2); extracellular transporters & carriers (APOE); G-protein coupled receptors (GNA13 and PTGIR); growth factors (MXD1); heat shock proteins (PRNP, HSPH1, and HSPD1); immune response (BST-1, CTSW, and IL1R1); interferons (INFGR1) intracellular kinases (WBP6); intracellular transducers (MAP3K7); kinase activators & inhibitors (YWHAH); membrane channels (KCNAB1, KCNJ12, KCNQ1, and SLC30A4); nucleotide metabolism (PCSK1); oncogenes & tumor suppressors (BRCA1, MAP3K8, RET, VIL2, FLI1, MET, NF2, and VEGFR1); receptor mediated endocytosis (DAB2); receptor tyrosine kinase (EPHA2); regulation of transcription (NEUROD6); serotonin biosynthesis (YTPH1); symporters & antiporters (SLC16A1 and SLC1A1); transcription activators & repressors (FOXA1, HSF1, IER2, and NR1H2); and synaptic transmission (GRID1).


Regulation (regulation) of VEGFR1 associated with cancer, shock, apoptosis, serotonin and adhesions
9) Confidence 0.03 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.72 Pain Relevance 0.11

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