INT200553

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.79
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
lung 6
epithelial cells 2
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 62.76 Quite High
ischemia 59 45.04 Quite Low
Somatostatin 2 14.32 Low Low
Inflammatory response 30 7.00 Low Low
anesthesia 22 5.00 Very Low Very Low Very Low
ketamine 11 5.00 Very Low Very Low Very Low
aspirin 10 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Corneal Neovascularization 74 99.58 Very High Very High Very High
Pre-eclampsia 208 99.40 Very High Very High Very High
Hypoxia 182 99.28 Very High Very High Very High
Targeted Disruption 33 99.10 Very High Very High Very High
Adult Respiratory Distress Syndrome 306 98.60 Very High Very High Very High
Death 135 98.48 Very High Very High Very High
Hyperoxia 42 98.24 Very High Very High Very High
Coronary Heart Disease 21 95.76 Very High Very High Very High
Hypertrophy 75 95.20 Very High Very High Very High
Hypertension 32 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of corneal neovascularization was associated with suppression of Vegfr2 but not Vegfr1 expression by exogenous vasohibin-1 signaling.
Negative_regulation (suppression) of Neg (not) Gene_expression (expression) of Vegfr1 associated with corneal neovascularization
1) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.60 Pain Relevance 0
Real-time quantitative RT–PCR was performed to determine the expression of Vegf and its receptors (Vegfr1, Vegfr2) as well as endogenous Vash1 between the treatment and control groups (Figure 5).
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of Vegfr1
2) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.08 Pain Relevance 0
The maternal concentration of sFlt1 tended to be higher at 36 weeks to term among the previous preeclampsia subjects with preeclampsia (p?
Negative_regulation (higher) of Gene_expression (concentration) of sFlt1 associated with pre-eclampsia
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 1.40 Pain Relevance 0
In the present study, IHC showed a significant decrease in the expression of VEGFR-1 in both the sham and the IIR groups, suggesting that hyperoxia and/or MV may suppress its expression.
Negative_regulation (decrease) of Gene_expression (expression) of VEGFR-1 associated with hyperoxia
4) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.45 Pain Relevance 0
The decreased expression level of VEGFR-1 was more significant in the IIR group (p < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of VEGFR-1
5) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.41 Pain Relevance 0
Decreased VEGFR-1 expression in the injured lung tissues
Negative_regulation (Decreased) of Gene_expression (expression) of VEGFR-1 in lung
6) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.11 Pain Relevance 0
We observed an increase of VEGF in the BAL, a decreased expression of VEGF and VEGFR-1, and an altered expression pattern of VEGFR-2 in the lung tissue.
Negative_regulation (decreased) of Gene_expression (expression) of VEGFR-1 in lung
7) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.34 Pain Relevance 0
These results suggest that VEGF may have dual roles in ALI: early release of VEGF may increase pulmonary vascular permeability; reduced expression of VEGF and VEGFR-1 in lung tissue may contribute to the death of alveolar epithelial cells.



Negative_regulation (reduced) of Gene_expression (expression) of VEGFR-1 in lung associated with adult respiratory distress syndrome and death
8) Confidence 0.22 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751039 Disease Relevance 0.55 Pain Relevance 0.03
Decreased expression of VEGF and VEGFR-1 in the lung tissue negatively correlated with death of alveolar epithelial cells.
Negative_regulation (Decreased) of Gene_expression (expression) of VEGFR-1 in epithelial cells associated with death
9) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.33 Pain Relevance 0
To substantiate the cause-effect relationship, future experiments using VEGFR-1 knock-out mice or siRNA approaches to selectively suppress VEGFR-1 expression in wild type animals are necessary.
Negative_regulation (suppress) of Gene_expression (expression) of VEGFR-1 associated with targeted disruption
10) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.37 Pain Relevance 0
, and the potential decoy VEGF receptor, VEGFR-1, and decreased expression of HIF-2?
Negative_regulation (decreased) of Gene_expression (expression) of VEGFR-1
11) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.62 Pain Relevance 0
To determine expression of those proteins, as well as their target genes VEGF and VEGFR-1/2, immunoblotting was performed (Figure 5) and densitometry data are summarized in Table 2.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of VEGFR-1/2
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.86 Pain Relevance 0
Thus pravastatin may prevent PE-specific features by restoring angiogenesis and placental development through two different mechanisms: decreasing sFlt-1 levels and increasing VEGF levels.
Negative_regulation (decreasing) of Gene_expression (levels) of sFlt-1 associated with pre-eclampsia
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.67 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox