INT200554

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 33.02
Pain Relevance 5.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 9
plasma 2
neutrophils 2
fat 1
capillary 1
Aliq1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 166 100.00 Very High Very High Very High
antagonist 120 99.74 Very High Very High Very High
ischemia 90 99.40 Very High Very High Very High
adenocard 584 99.24 Very High Very High Very High
fibrosis 69 99.24 Very High Very High Very High
Inflammation 491 99.08 Very High Very High Very High
agonist 104 98.92 Very High Very High Very High
Inflammatory stimuli 8 94.56 High High
cytokine 191 89.80 High High
Inflammatory response 86 84.84 Quite High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 1678 100.00 Very High Very High Very High
Hemorrhage 164 100.00 Very High Very High Very High
Hyperoxia 79 99.98 Very High Very High Very High
Lung Injury 346 99.92 Very High Very High Very High
Respiratory Failure 23 99.92 Very High Very High Very High
Cv General 4 Under Development 62 99.84 Very High Very High Very High
Sepsis 73 99.80 Very High Very High Very High
Pneumonia 194 99.70 Very High Very High Very High
Pulmonary Fibrosis 52 99.44 Very High Very High Very High
INFLAMMATION 417 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the induction of ALI, the intensity of staining for NEP in the alveolar wall appeared lower with the destruction of the walls and sloughing of the epithelial cells.
Positive_regulation (induction) of ALI in alveolar wall associated with adult respiratory distress syndrome
1) Confidence 0.22 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.28 Pain Relevance 0.03
In an experimental study, we induced ALI by intratracheal instillation of hydrochloric acid (HCl) or lipopolysaccharide (LPS) in mice, and similarly measured NEP activity in plasma, lung tissue, and broncho-alveolar lavage fluid (BALF).
Positive_regulation (induced) of ALI in lung associated with adult respiratory distress syndrome
2) Confidence 0.13 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 1.32 Pain Relevance 0.04
On the other hand, a decrease in NEP activity in plasma has been reported during septic shock, a major cause of ALI/ARDS [21].
Positive_regulation (cause) of ALI/ARDS in plasma associated with adult respiratory distress syndrome and sepsis
3) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.98 Pain Relevance 0
Thus, the NEP expression was most likely down-regulated on the PMN that were recruited and activated during ALI/ARDS.
Positive_regulation (activated) of ALI/ARDS associated with adult respiratory distress syndrome
4) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.16 Pain Relevance 0.13
These attributes make APC an attractive consideration for clinical conditions associated with increased microvascular permeability in general, including ALI, irrespective of the presence of sepsis.
Positive_regulation (increased) of ALI associated with adult respiratory distress syndrome and sepsis
5) Confidence 0.11 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 1.08 Pain Relevance 0
We hypothesized that high-tidal-volume ventilation after bleomycin-induced ALI can increase lung fibrosis secondary to activation of the Akt and MAPK pathways.


Positive_regulation (induced) of ALI in lung associated with fibrosis, pulmonary fibrosis and adult respiratory distress syndrome
6) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.66 Pain Relevance 0.15
In the present study, we used IIR to induce ALI in hTF-KI mice.
Positive_regulation (induce) of ALI associated with adult respiratory distress syndrome
7) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.73 Pain Relevance 0.19
Administration of CNTO859 ameliorated IIR-induced ALI
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.58 Pain Relevance 0.05
ALI was induced in piglets by intravenous infusion of oleic acid, and mechanical ventilation with low Vt was initiated.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
9) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592724 Disease Relevance 0.76 Pain Relevance 0
Also clinically relevant is the fact that treatment after induction of ALI had similar effects, albeit to a lesser extent [49].
Positive_regulation (induction) of ALI associated with adult respiratory distress syndrome
10) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.90 Pain Relevance 0.27
ALI was enhanced in CD39-/- and CD73-/- mice, as indicated by impaired oxygenation and increased protein content of the BAL fluid, increased PMN infiltration, and increased lung water content [35].
Positive_regulation (enhanced) of ALI in lung associated with adult respiratory distress syndrome
11) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.64 Pain Relevance 0.38
Protective effects on pulmonary microvascular leakage have also been demonstrated in the model of fat emulsion induced ALI [33], implicating adenosine as a key molecule in the regulation of endothelial integrity and pulmonary fluid balance.
Positive_regulation (induced) of ALI in fat associated with adenocard and adult respiratory distress syndrome
12) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.74 Pain Relevance 0.40
We then investigated the alterations of VEGF and its receptors in IIR-induced ALI.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
13) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.37 Pain Relevance 0
These findings suggest that upregulation of adenosine production in response to mechanical ventilation mediates protection from ALI.
Positive_regulation (mediates) of ALI associated with adenocard and adult respiratory distress syndrome
14) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.69 Pain Relevance 0.40
However, the fact that specific A2A agonists are currently being tested in clinical trials for other diseases makes this receptor an attractive target for therapeutic advancement in human ALI/ARDS.
Positive_regulation (advancement) of ALI associated with agonist, adult respiratory distress syndrome and disease
15) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.81 Pain Relevance 0.27
In a model of hemorrhage-induced ALI, pretreatment with an A2A agonist attenuated increases in both PMN sequestration into the lung and microvascular permeability.
Positive_regulation (induced) of ALI in lung associated with agonist, adult respiratory distress syndrome and cva
16) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.70 Pain Relevance 0.24
Consistent with these data, pretreatment with an A1 antagonist blocked the increase in pulmonary capillary filtration in a canine model of ALI [42].
Positive_regulation (increase) of ALI in capillary associated with antagonist and adult respiratory distress syndrome
17) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.92 Pain Relevance 0.26
In a murine model of combined pneumonia and hyperoxia induced ALI, organ damage was attenuated and survival was prolonged after treatment with an A2A agonist [50].
Positive_regulation (induced) of ALI associated with hyperoxia, agonist, adult respiratory distress syndrome and pneumonia
18) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.20 Pain Relevance 0.52
In conclusion, GMCSF plays an important role in not only LPS-induced but also hemorrhage-induced ALI by its priming effects on neutrophils.



Positive_regulation (induced) of ALI in neutrophils associated with adult respiratory distress syndrome and cva
19) Confidence 0.05 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.92 Pain Relevance 0.38
The expression of PC III was higher in the rats with ALI induced by oleic acid/high Vt/low PEEP in the supine position and ALI from oleic acid/low Vt/high PEEP in the supine position compared with control rats treated with oleic acid, but not mechanically ventilated.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
20) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2592724 Disease Relevance 0.76 Pain Relevance 0

General Comments

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