INT2006

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Context Info
Confidence 0.34
First Reported 1979
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 104
Total Number 107
Disease Relevance 64.91
Pain Relevance 19.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocyte 6
Platelet 3
CD86 3
macrophages 2
plaque 2
fc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 571 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
rheumatoid arthritis 2416 99.80 Very High Very High Very High
Pain 66 99.64 Very High Very High Very High
Infliximab 19 99.44 Very High Very High Very High
Arthritis 1103 99.24 Very High Very High Very High
Potency 2 99.18 Very High Very High Very High
Inflammatory response 85 99.12 Very High Very High Very High
Inflammation 918 98.92 Very High Very High Very High
Etanercept 20 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 251 99.98 Very High Very High Very High
Rheumatoid Arthritis 2429 99.80 Very High Very High Very High
Systemic Lupus Erythematosus 381 99.66 Very High Very High Very High
Pain 59 99.64 Very High Very High Very High
Increased Venous Pressure Under Development 20 99.32 Very High Very High Very High
Arthritis 1121 99.24 Very High Very High Very High
Arthus Reaction 112 99.20 Very High Very High Very High
Pulmonary Disease 14 99.20 Very High Very High Very High
Multiple Sclerosis 32 99.16 Very High Very High Very High
INFLAMMATION 1044 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, pre-implantation systemic as well as post-implantation intra-tumor injection of TNFR:Fc partially blocked the mechanical hyperalgesia, indicating that local production of TNF-alpha may contribute to tumor-induced nociception.
Gene_expression (injection) of Fc associated with nociception, hyperalgesia and cancer
1) Confidence 0.34 Published 2005 Journal Neuroscience Section Abstract Doc Link 15802198 Disease Relevance 1.80 Pain Relevance 0.42
R- /- mice, in which the surface expression of Fc?
Gene_expression (expression) of Fc
2) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.58 Pain Relevance 0.41
B7-H4Ig and the control vector were transfected into 293 T cells and the same level of production of Fc was confirmed with two plasmids (unpublished data).
Gene_expression (production) of Fc in T cells
3) Confidence 0.22 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.65 Pain Relevance 0.36
The particular receptor responsible for maintaining IgG titers in blood is the intracellular Fc receptor (FcRn) that is abundantly expressed in endothelial cells.
Gene_expression (expressed) of Fc in endothelial cells
4) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.00 Pain Relevance 0.23
It has also been shown that deletion of Fc?
Gene_expression (deletion) of Fc
5) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.55 Pain Relevance 0.44
Studies on relative contributions of either complement or Fc?
Gene_expression (Studies) of Fc
6) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.39 Pain Relevance 0.44
C5a increased the expression of activating Fc?
Gene_expression (expression) of Fc
7) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.00 Pain Relevance 0.19
chain of the Fc?
Gene_expression (chain) of Fc
8) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.45 Pain Relevance 0.36
Arthritis-susceptible DBA/1 mice that are also deficient in the inhibitory receptor Fc?
Gene_expression (deficient) of Fc associated with arthritis
9) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.43 Pain Relevance 0.47
Mice lacking the stimulatory Fc?
Neg (lacking) Gene_expression (lacking) of Fc
10) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.17 Pain Relevance 0.23
RIII is downregulated, the inflammatory response in the reverse Arthus reaction in skin, peritoneum and lung is impaired, arguing for the predominance of Fc?
Gene_expression (predominance) of Fc in lung associated with inflammatory response and arthus reaction
11) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.44 Pain Relevance 0.35
The complement system mediators such as complement component 5a (C5a) might be crucial in the communication between the complement system and Fc?
Gene_expression (system) of Fc
12) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175042 Disease Relevance 0.25 Pain Relevance 0.09
Rs in the inflammatory response, especially in Arthus reaction mice models, have resulted in a better understanding of the role of the complement system and Fc?
Gene_expression (understanding) of Fc associated with inflammatory response and arthus reaction
13) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.54 Pain Relevance 0.41
RIII and decreased the expression of the inhibitory Fc?
Gene_expression (expression) of Fc
14) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.98 Pain Relevance 0.19
Expression in vivo of an agonist, a B7-H4-immunoglobulin Fc fusion protein, profoundly suppressed disease progression in the mouse model.


Gene_expression (on) of Fc associated with agonist and disease progression
15) Confidence 0.15 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2760136 Disease Relevance 1.25 Pain Relevance 0.47
Furthermore, in formalin inflammation pain model, pre-inhibition of EphBs receptors by the injection of EphB1-Fc reduces pain behavior, which is accompanied by the decreased expression of peripheral p-p38, pERK and pJNK.
Gene_expression (injection) of EphB1-Fc associated with pain and inflammation
16) Confidence 0.13 Published 2008 Journal Pain Section Abstract Doc Link 18706764 Disease Relevance 0.60 Pain Relevance 0.72
The proportion of T lymphocytes with receptors for the Fc portion of IgG (TG cells) of IgM (TM cells) was determined in synovial fluid and blood of 16 patients with various rheumatic diseases including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
Gene_expression (portion) of Fc in T lymphocytes associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, rheumatic diseases and arthritis
17) Confidence 0.12 Published 1979 Journal Arthritis Rheum. Section Abstract Doc Link 314294 Disease Relevance 0.45 Pain Relevance 0.19
This study shows that intraplantar (i.pl.) injection of ephrinB1-Fc produces a dose- and time-dependent thermal and mechanical hyperalgesia and the increase of spinal Fos protein expression in mice, which can be partially prevented by pre-treatment with EphB1-Fc.
Gene_expression (produces) of ephrinB1-Fc in spinal associated with hyperalgesia
18) Confidence 0.11 Published 2008 Journal Pain Section Abstract Doc Link 18706764 Disease Relevance 0.51 Pain Relevance 0.53
RIIb [14] and an elevated expression of Fc?
Gene_expression (expression) of Fc
19) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.34 Pain Relevance 0.25
In our sample of healthy subjects, we detected that most individuals upregulate the expression of Fc?
Gene_expression (expression) of Fc
20) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.67 Pain Relevance 0.29

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