INT20060

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Context Info
Confidence 0.56
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.22
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
muscle 1
lateral 1
ganglia 1
motoneurons 1
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 8 99.08 Very High Very High Very High
Dorsal horn 10 98.12 Very High Very High Very High
Dopamine 2 97.92 Very High Very High Very High
Spinal cord 8 97.36 Very High Very High Very High
electroacupuncture 4 95.62 Very High Very High Very High
analgesia 10 90.62 High High
cocaine 1 89.40 High High
cerebral cortex 9 89.00 High High
Desipramine 1 88.96 High High
Norepinephrine uptake inhibitor 1 88.48 High High
Disease Link Frequency Relevance Heat
Muscular Atrophy 1 96.00 Very High Very High Very High
Paralysis 1 69.52 Quite High
Cirrhosis 19 57.68 Quite High
Shock 2 47.52 Quite Low
Liver Disease 8 33.36 Quite Low
Hepatic Encephalopathy 17 5.00 Very Low Very Low Very Low
Cognitive Disorder 11 5.00 Very Low Very Low Very Low
Liver Failure 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low
Hyperammonemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that motoneurons control the stability of junctional AChRs through evoked muscle activity and the number of junctional AChRs through trophic factors.
Protein_catabolism (stability) of AChRs in motoneurons
1) Confidence 0.56 Published 1990 Journal Neuron Section Abstract Doc Link 2322461 Disease Relevance 0.17 Pain Relevance 0.07
The action of ACh was not modified by the presence of nomifensine, a dopamine uptake inhibitor.
Protein_catabolism (action) of ACh associated with dopamine
2) Confidence 0.56 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6150107 Disease Relevance 0 Pain Relevance 0.46
The results are consistent with previous studies showing that blocking the enzymatic degradation of ACh in XII significantly inhibited tongue muscle activity.


Protein_catabolism (degradation) of ACh in muscle
3) Confidence 0.55 Published 2007 Journal Sleep Section Body Doc Link 17552371 Disease Relevance 0 Pain Relevance 0
The results were found that: 1) EA at "huantiao" exerted a marked analgesia effect, the acupuncture analgesia was inhibited when the lateral dorsal root was cut off. 2) The content of ACh of the EA group were slightly lower than those of the control group. 3) AChE activity in the spinal ganglia and the dorsal horn increased markedly under electroacupuncture stimulation. 4) The activity of ChAC in the dorsal horn of rats under acupuncture stimulation was significantly higher than those of the control group. 5) ACh content in the spinal ganglia increased obviously when the degradation of peripheral ACh was inhibited by prostigmine. 6) With the lumber dorsal roots excised, AChE activity of the operative side were much lower than those of the intact side during EA stimulation.
Protein_catabolism (degradation) of ACh in lateral associated with dorsal horn, acupuncture, electroacupuncture and analgesia
4) Confidence 0.30 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2118000 Disease Relevance 0 Pain Relevance 1.08
In this paper a preliminary study was made about the relationship between ACh and the primary input of acupuncture sensation based on the changes of content of ACh, its synthetic enzyme (choline acetylase, or ChAC) and its degradation enzyme (acetylcholinesterase, or AChE) in the dorsal horn of the spinal cord and spinal ganglia.
Protein_catabolism (degradation) of ACh in ganglia associated with dorsal horn, acupuncture and spinal cord
5) Confidence 0.30 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2118000 Disease Relevance 0 Pain Relevance 0.75
M of the cholinesterase inhibitor neostigmine in the perfused solution, which is necessary to avoid degradation of ACh in the extracellular space.
Protein_catabolism (degradation) of ACh
6) Confidence 0.16 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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