INT20064

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2006
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.05
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
neurons 2
brain 2
striatum 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 42 100.00 Very High Very High Very High
monoamine 2 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Eae 4 99.60 Very High Very High Very High
Dynorphin 1 98.92 Very High Very High Very High
GABAergic 5 98.32 Very High Very High Very High
tetrodotoxin 3 98.12 Very High Very High Very High
projection neuron 1 97.92 Very High Very High Very High
Opioid 7 94.32 High High
withdrawal 2 88.48 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 7 100.00 Very High Very High Very High
Obesity 3 98.50 Very High Very High Very High
Body Weight 1 94.04 High High
Targeted Disruption 6 92.40 High High
Convulsion 1 90.36 High High
Sperm Disorder 1 86.96 High High
Alcohol Addiction 1 82.84 Quite High
Disease 4 75.00 Quite High
Death 1 71.80 Quite High
Generalized Anxiety Disorder 1 71.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During electrical blockade, none of the concentrations of NMDA tested showed any effect on enkephalin expression, neither could NMDA pre-treatment prevent the TTX-induced down-regulation of mRNAppENK.
Regulation (effect) of Gene_expression (expression) of enkephalin associated with tetrodotoxin and enkephalin
1) Confidence 0.47 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8353931 Disease Relevance 0 Pain Relevance 0.74
At 6 to 8 weeks, an age prior to the onset of obesity, levels of dynorphin peptides are decreased in all brain regions, whereas levels of ir-Met-enkephalin are differentially altered.
Regulation (altered) of Gene_expression (levels) of ir-Met-enkephalin in brain associated with dynorphin, obesity and enkephalin
2) Confidence 0.27 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438557 Disease Relevance 0.26 Pain Relevance 0.59
In contrast, ethanol treatment did not affect Met-enkephalin levels in the striatal tissue.
Neg (not) Regulation (affect) of Gene_expression (levels) of Met-enkephalin associated with enkephalin
3) Confidence 0.20 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.15 Pain Relevance 0.81
[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Regulation ([Effects) of Gene_expression (levels) of enkephalin associated with parkinson's disease, enkephalin and monoamine
4) Confidence 0.10 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Title Doc Link 2118063 Disease Relevance 0.54 Pain Relevance 1.00
D2R might be involved in the regulation of enkephalin expression in the striatum, and hence might affect the movement and the behaviour.


Regulation (regulation) of Gene_expression (expression) of enkephalin in striatum
5) Confidence 0.09 Published 1996 Journal Genes Cells Section Body Doc Link 9140068 Disease Relevance 0 Pain Relevance 0
Single-cell RT-PCR studies also examined neurons for the expression of substance P and enkephalin to define different subpopulations of medium-sized projection neurons of the striatum.
Spec (examined) Regulation (neurons) of Spec (examined) Gene_expression (expression) of enkephalin in neurons associated with projection neuron, enkephalin and substance p
6) Confidence 0.08 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.38 Pain Relevance 0.49
Also no change in enkephalin biosynthesis was detectable by in situ methods quantifying striatal proenkephalin-mRNA levels in NEP-deficient mice compared with wildtype.
Neg (no) Regulation (change) of Gene_expression (biosynthesis) of enkephalin associated with enkephalin
7) Confidence 0.07 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11102652 Disease Relevance 0.32 Pain Relevance 0.66
In situ hybridization showed that after injecting muscimol in the D2R-/- mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation.
Regulation (regulated) of Gene_expression (expression) of enkephalin associated with gabaergic, eae and enkephalin
8) Confidence 0.06 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15080900 Disease Relevance 0.16 Pain Relevance 0.69
Altered enkephalin expression may affect testicular function.
Regulation (Altered) of Gene_expression (expression) of enkephalin associated with enkephalin
9) Confidence 0.03 Published 1994 Journal Mol. Reprod. Dev. Section Abstract Doc Link 7917279 Disease Relevance 0.23 Pain Relevance 0.19

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