INT20066

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Context Info
Confidence 0.76
First Reported 1987
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 21.41
Pain Relevance 13.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mdk) extracellular region (Mdk)
Anatomy Link Frequency
neuron 7
neuronal 3
IEC-6 2
liver 1
spinal cords 1
Mdk (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 43 100.00 Very High Very High Very High
Enkephalin 33 100.00 Very High Very High Very High
Hyperalgesia 29 99.96 Very High Very High Very High
analgesia 1 99.84 Very High Very High Very High
Thermal hyperalgesia 230 99.82 Very High Very High Very High
Acupuncture 1 99.64 Very High Very High Very High
Eae 132 99.32 Very High Very High Very High
Arthritis 192 99.12 Very High Very High Very High
substance P 146 99.04 Very High Very High Very High
Inflammation 274 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 13 100.00 Very High Very High Very High
Hyperalgesia 259 99.96 Very High Very High Very High
Reprotox - General 1 285 99.74 Very High Very High Very High
Skin Cancer 145 99.70 Very High Very High Very High
Parkinson's Disease 14 99.68 Very High Very High Very High
Hepatocellular Cancer 72 99.60 Very High Very High Very High
Adhesions 15 99.52 Very High Very High Very High
Inflammatory Pain 99 99.32 Very High Very High Very High
Targeted Disruption 80 99.16 Very High Very High Very High
Arthritis 186 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of persistent activation of ERK with either MEK inhibitors, or with overexpression of dominant negative MEK in the cultures, resulted in a decrease in cell death of the CGN [42,43].
Gene_expression (overexpression) of MEK in CGN associated with death
1) Confidence 0.76 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.43 Pain Relevance 0.42
Sorafenib is a first-generation non-selective RAF inhibitor that has been shown to abrogate MAPK signaling biochemically and to harbor anti-melanoma effects in vitro.[41] Early clinical trials have failed to show significant efficacy with sorafenib as monotherapy in advanced melanoma.[4] While recent results with sorafenib in combination with carboplatin and paclitaxel have not been very promising,[42] in cases where pre-treatment pharmacogenomic screening for the expression of sorafenib targets was performed, specific benefits have been reported.[43] More specifically, high VEGF -R2 expression is associated with response to sorafenib, carboplatin, and paclitaxel combination treatment in melanoma, whereas high MEK expression is associated with resistance [Figure 1].[43]

MEK

Gene_expression (expression) of MEK associated with skin cancer
2) Confidence 0.75 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 0.52 Pain Relevance 0
Twelve days after the last MPTP injection, the levels of methionine-enkephalin (MEK) and leucine-enkephalin (LEK) in the mice striatum bodies were determined with radioimmunoassay.
Spec (determined) Gene_expression (levels) of MEK in striatum associated with parkinson's disease and enkephalin
3) Confidence 0.69 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Abstract Doc Link 2118063 Disease Relevance 0.53 Pain Relevance 0.99
Although basal phosphorylated ERK is minimal in mouse spinal cords without noxious stimuli, we investigated whether expression of the DN MEK transgene would alter basal ERK activation in the DN MEK mice.
Spec (whether) Gene_expression (expression) of DN MEK in spinal cords
4) Confidence 0.66 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.52 Pain Relevance 0.41
Inhibition of persistent activation of ERK with either MEK inhibitors, or with overexpression of dominant negative MEK in the cultures, resulted in a decrease in cell death of the CGN [42,43].
Gene_expression (overexpression) of MEK in CGN associated with death
5) Confidence 0.66 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.43 Pain Relevance 0.42
Rats gavaged with an amount of milk equal in calories to dark ad lib-fed rats (light-fasted) had MEK concentrations not different from light-fasted non-fed rats (216 vs. 209 pg/mg tissue, NS) suggesting that feeding behavior, pregastric stimuli and/or form of diet is important for influencing MEK concentrations.
Gene_expression (concentrations) of MEK associated with enkephalin
6) Confidence 0.59 Published 1987 Journal Physiol. Behav. Section Abstract Doc Link 3432401 Disease Relevance 0 Pain Relevance 0.66
We tested mutant mice that express dominant negative MEK, whose expression was driven by the pan-neuronal and neuron-specific Talpha1 alpha-tubulin promoter, such that the dominant negative MEK protein is expressed only in neurons.
Gene_expression (expression) of MEK in neuron
7) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.53 Pain Relevance 0.45
We tested mutant mice that express dominant negative MEK, whose expression was driven by the pan-neuronal and neuron-specific Talpha1 alpha-tubulin promoter, such that the dominant negative MEK protein is expressed only in neurons.
Neg (negative) Gene_expression (expressed) of MEK in neuron
8) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.54 Pain Relevance 0.42
Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

Background

Gene_expression (expressing) of MEK in neuron associated with thermal hyperalgesia and eae
9) Confidence 0.59 Published 2006 Journal Mol Pain Section Title Doc Link PMC1382249 Disease Relevance 0.69 Pain Relevance 0.53
We tested mutant mice that express dominant negative MEK, whose expression was driven by the pan-neuronal and neuron-specific Talpha1 alpha-tubulin promoter, such that the dominant negative MEK protein is expressed only in neurons.
Neg (negative) Gene_expression (express) of MEK in neuron
10) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.53 Pain Relevance 0.45
Female mice of both groups (wild type and DN MEK) express more thermal hyperalgesia compared to the male mice (P < 0.001).
Gene_expression (express) of DN MEK associated with thermal hyperalgesia
11) Confidence 0.57 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.99 Pain Relevance 0.78
We studied the effect of acupuncture analgesia on the expression of ppENKmRNA, MEK-IR, and Dyn-IR in circulating mouse lymphocytes.
Gene_expression (expression) of MEK-IR in lymphocytes associated with acupuncture and analgesia
12) Confidence 0.54 Published 2005 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 16224585 Disease Relevance 0 Pain Relevance 0.24
The levels of MEK and LEK in the mice receiving the monoamine oxidase inhibitor as well as MPTP did not differ significantly from the levels in the controls.
Gene_expression (levels) of MEK in LEK associated with parkinson's disease, enkephalin and monoamine
13) Confidence 0.53 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Abstract Doc Link 2118063 Disease Relevance 0.52 Pain Relevance 1.08
The generation of the DN MEK mice has been previously described [31].
Gene_expression (generation) of DN MEK
14) Confidence 0.51 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 1.02 Pain Relevance 0.53
MDK expression is negatively regulated by androgen [65].
Gene_expression (expression) of MDK
15) Confidence 0.48 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.85 Pain Relevance 0
In contrast to earlier reports in which MDK gene and protein expression was determined to be higher in late stage cancer [63,142], we observed a drop in the levels of MDK mRNA in CRPC versus RAD.
Gene_expression (expression) of MDK associated with cancer and reprotox - general 1
16) Confidence 0.48 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.83 Pain Relevance 0
Gene expression trends of GLO1 [135], S100A10 [136], TRPM8 [137], and PI3KCD [138] suggest cell survival pathways are active following androgen-deprivation and/or in CRPC, while gene expression trends of CAMK2N1 [139], CCT2 [140], MDK [141,142], TMEM66 [143], and YWHAQ [136] may oppose such suggestion.
Gene_expression (expression) of MDK associated with reprotox - general 1
17) Confidence 0.42 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.66 Pain Relevance 0.05
Moreover, RACK1 is associated with the core kinases of the ERK pathway, Raf, MEK, and ERK.
Gene_expression (pathway) of MEK
18) Confidence 0.36 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.60
Since our in vitro study indicated that MEK1/2 activity was required for the survival of liver cancer cells, transfection studies were performed to determine whether over-expression of MEK-MAPK would protect cells from U0126-induced apoptosis and enhance tumor growth in vivo.
Gene_expression (expression) of MEK in liver associated with liver cancer, cancer and apoptosis
19) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.40 Pain Relevance 0
Nevertheless, Thiel et al. [82] showed that the selective MEK SMI, PD184352 suppressed murine CIA paw edema and clinical arthritis scores while also reducing IL-1?
Gene_expression (selective) of MEK SMI in paw associated with pressure and volume under development and arthritis
20) Confidence 0.21 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.93 Pain Relevance 0.38

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