INT200666

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.23
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
neuronal 1
AKT1 (Homo sapiens)
AKT1 - E17K (1)
Pain Link Frequency Relevance Heat
Inflammation 73 77.60 Quite High
addiction 1 71.92 Quite High
Inflammatory mediators 14 71.00 Quite High
ischemia 1 64.08 Quite High
Central nervous system 31 60.64 Quite High
Inflammatory marker 4 50.00 Quite Low
Inflammatory response 6 45.32 Quite Low
chemokine 36 27.16 Quite Low
Multiple sclerosis 4 9.36 Low Low
cytokine 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 247 100.00 Very High Very High Very High
Endometrial Cancer 67 97.40 Very High Very High Very High
Death 85 91.52 High High
Cancer 142 90.88 High High
Microsatellite Instability 15 78.48 Quite High
INFLAMMATION 99 77.60 Quite High
Cervical Cancer 15 76.52 Quite High
Repression 6 69.28 Quite High
Metaplasia 1 64.60 Quite High
Cv General 4 Under Development 1 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that these inhibitors repress Akt1 and Akt2 transcription thereby depleting the cellular Akt protein.
Transcription (transcription) of Akt1
1) Confidence 0.66 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.58 Pain Relevance 0
The negative effect of valproic acid or butyrate on Akt expression could be mediated through a direct or indirect mechanism, i.e. through inhibiting deacetylation of nonhistone proteins, such as transcription regulators, or gene activation of some negative regulators of Akt gene transcription.
Transcription (transcription) of Akt gene
2) Confidence 0.66 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.37 Pain Relevance 0
Next, we performed quantitative real-time RT-PCR analysis to assess the mRNA levels of Akt isoforms.
Transcription (levels) of Akt
3) Confidence 0.49 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.26 Pain Relevance 0
However, Shoji et al. reported that AKT1 (E17K) mutations were detected in 2 out of 89 tissue samples and 0 out of 12 cell lines [24].
Transcription (detected) of AKT1 (E17K)
4) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.03 Pain Relevance 0.04
No significant difference was observed between any treatment groups for mRNA expression for PKB, mTOR, p70S6k, GSK-3?
Transcription (expression) of PKB
5) Confidence 0.17 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
IGF-I regulates survival at the nuclear level through accumulation of phospho-Akt in DRG neuronal nuclei, increased CREB-mediated transcription, and nuclear exclusion of FKHR.
Transcription (transcription) of Akt in neuronal
6) Confidence 0.12 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.10 Pain Relevance 0.06
This conclusion was founded on the observed upregulation in transcripts for AKT1 and Bcl-XL, paired with decreased gene expression for DRAM.
Transcription (transcripts) of AKT1
7) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.55 Pain Relevance 0.10
In cultures containing only SY cells and B. burgdorferi, there were prominent increases in transcript for the cell survival and anti-apoptotic molecules protein kinase B (AKT1) and BCL2-like (Bcl-XL) genes, combined with a decrease in transcript for pro-apoptotic damage-regulated autophagy modulator (DRAM) (Table 6-left, Figure 4A).
Transcription (transcript) of AKT1 associated with apoptosis
8) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.35 Pain Relevance 0

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