INT200669

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2)
carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)
Anatomy Link Frequency
paw 1
AKT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 100.00 Very High Very High Very High
intrathecal 14 98.72 Very High Very High Very High
allodynia 2 94.88 High High
Brush evoked pain 20 88.60 High High
Peripheral nerve injury 5 65.20 Quite High
Stimulus evoked pain 2 54.04 Quite High
Neuropathic pain 15 52.04 Quite High
Dorsal horn neuron 8 50.68 Quite High
Thermal hyperalgesia 1 46.56 Quite Low
Spinal cord 11 17.92 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 37 94.88 High High
Death 25 78.48 Quite High
Apoptosis 41 74.28 Quite High
Cervical Cancer 5 66.88 Quite High
Nervous System Injury 17 65.20 Quite High
Hypersensitivity 2 54.04 Quite High
Pain 9 53.36 Quite High
Cancer 26 50.00 Quite Low
Hyperalgesia 1 46.56 Quite Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the previous results in mice [24], intrathecal pretreatment with AG17 (100 nmol) significantly attenuated the decrease in the paw withdrawal threshold 7 days after PDGF administration (PDGF-BB + vehicle group, 1.71 ± 0.41, n = 4; PDGF-BB + AG17 group, 9.43 ± 1.13, n = 4; P < 0.001).
Negative_regulation (decrease) of -BB in paw associated with withdrawal and intrathecal
1) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.54 Pain Relevance 0.72
As shown in Fig. 1B, following 16 hours of butyrate treatment, the levels of Akt1 and Akt2 mRNA were reduced by about 70% and 50% respectively as compared to untreated control cells.
Negative_regulation (reduced) of Akt2 mRNA
2) Confidence 0.38 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.40 Pain Relevance 0

General Comments

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